Ventral tegmental area dopamine revisited: effects of acute and repeated stress
Aversive events rapidly and potently excite certain dopamine neurons in the ventral tegmental area (VTA), promoting phasic increases in the medial prefrontal cortex and nucleus accumbens. This is in apparent contradiction to a wealth of literature demonstrating that most VTA dopamine neurons are str...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer Berlin Heidelberg
2016
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| Online Access: | http://hdl.handle.net/1721.1/104043 |
| _version_ | 1811081019445477376 |
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| author | Holly, Elizabeth N. Miczek, Klaus A. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Holly, Elizabeth N. Miczek, Klaus A. |
| author_sort | Holly, Elizabeth N. |
| collection | MIT |
| description | Aversive events rapidly and potently excite certain dopamine neurons in the ventral tegmental area (VTA), promoting phasic increases in the medial prefrontal cortex and nucleus accumbens. This is in apparent contradiction to a wealth of literature demonstrating that most VTA dopamine neurons are strongly activated by reward and reward-predictive cues while inhibited by aversive stimuli. How can these divergent processes both be mediated by VTA dopamine neurons? The answer may lie within the functional and anatomical heterogeneity of the VTA. We focus on VTA heterogeneity in anatomy, neurochemistry, electrophysiology, and afferent/efferent connectivity. Second, recent evidence for a critical role of VTA dopamine neurons in response to both acute and repeated stress will be discussed. Understanding which dopamine neurons are activated by stress, the neural mechanisms driving the activation, and where these neurons project will provide valuable insight into how stress can promote psychiatric disorders associated with the dopamine system, such as addiction and depression. |
| first_indexed | 2024-09-23T11:40:30Z |
| format | Article |
| id | mit-1721.1/104043 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:40:30Z |
| publishDate | 2016 |
| publisher | Springer Berlin Heidelberg |
| record_format | dspace |
| spelling | mit-1721.1/1040432022-09-27T21:11:00Z Ventral tegmental area dopamine revisited: effects of acute and repeated stress Holly, Elizabeth N. Miczek, Klaus A. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Holly, Elizabeth N. Aversive events rapidly and potently excite certain dopamine neurons in the ventral tegmental area (VTA), promoting phasic increases in the medial prefrontal cortex and nucleus accumbens. This is in apparent contradiction to a wealth of literature demonstrating that most VTA dopamine neurons are strongly activated by reward and reward-predictive cues while inhibited by aversive stimuli. How can these divergent processes both be mediated by VTA dopamine neurons? The answer may lie within the functional and anatomical heterogeneity of the VTA. We focus on VTA heterogeneity in anatomy, neurochemistry, electrophysiology, and afferent/efferent connectivity. Second, recent evidence for a critical role of VTA dopamine neurons in response to both acute and repeated stress will be discussed. Understanding which dopamine neurons are activated by stress, the neural mechanisms driving the activation, and where these neurons project will provide valuable insight into how stress can promote psychiatric disorders associated with the dopamine system, such as addiction and depression. 2016-08-26T17:52:36Z 2017-03-01T16:14:48Z 2015-12 2015-08 2016-05-23T12:09:11Z Article http://purl.org/eprint/type/JournalArticle 0033-3158 1432-2072 http://hdl.handle.net/1721.1/104043 Holly, Elizabeth N., and Klaus A. Miczek. “Ventral Tegmental Area Dopamine Revisited: Effects of Acute and Repeated Stress.” Psychopharmacology 233, no. 2 (December 17, 2015): 163-186. en http://dx.doi.org/10.1007/s00213-015-4151-3 Psychopharmacology Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. Springer-Verlag Berlin Heidelberg application/pdf Springer Berlin Heidelberg Springer Berlin Heidelberg |
| spellingShingle | Holly, Elizabeth N. Miczek, Klaus A. Ventral tegmental area dopamine revisited: effects of acute and repeated stress |
| title | Ventral tegmental area dopamine revisited: effects of acute and repeated stress |
| title_full | Ventral tegmental area dopamine revisited: effects of acute and repeated stress |
| title_fullStr | Ventral tegmental area dopamine revisited: effects of acute and repeated stress |
| title_full_unstemmed | Ventral tegmental area dopamine revisited: effects of acute and repeated stress |
| title_short | Ventral tegmental area dopamine revisited: effects of acute and repeated stress |
| title_sort | ventral tegmental area dopamine revisited effects of acute and repeated stress |
| url | http://hdl.handle.net/1721.1/104043 |
| work_keys_str_mv | AT hollyelizabethn ventraltegmentalareadopaminerevisitedeffectsofacuteandrepeatedstress AT miczekklausa ventraltegmentalareadopaminerevisitedeffectsofacuteandrepeatedstress |