Determinants of specificity in two-component signal transduction
Maintaining the faithful flow of information through signal transduction pathways is critical to the survival and proliferation of organisms. This problem is particularly challenging as many signaling proteins are part of large, paralogous families that are highly similar at the sequence and structu...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2016
|
| Online Access: | http://hdl.handle.net/1721.1/104060 https://orcid.org/0000-0002-8288-7607 |
| _version_ | 1826198677373321216 |
|---|---|
| author | Podgornaia, Anna Igorevna Laub, Michael T |
| author2 | Massachusetts Institute of Technology. Computational and Systems Biology Program |
| author_facet | Massachusetts Institute of Technology. Computational and Systems Biology Program Podgornaia, Anna Igorevna Laub, Michael T |
| author_sort | Podgornaia, Anna Igorevna |
| collection | MIT |
| description | Maintaining the faithful flow of information through signal transduction pathways is critical to the survival and proliferation of organisms. This problem is particularly challenging as many signaling proteins are part of large, paralogous families that are highly similar at the sequence and structural levels, increasing the risk of unwanted cross-talk. To detect environmental signals and process information, bacteria rely heavily on two-component signaling systems comprised of sensor histidine kinases and their cognate response regulators. Although most species encode dozens of these signaling pathways, there is relatively little cross-talk, indicating that individual pathways are well insulated and highly specific. Here, we review the molecular mechanisms that enforce this specificity. Further, we highlight recent studies that have revealed how these mechanisms evolve to accommodate the introduction of new pathways by gene duplication. |
| first_indexed | 2024-09-23T11:08:25Z |
| format | Article |
| id | mit-1721.1/104060 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:08:25Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1040602022-10-01T01:32:13Z Determinants of specificity in two-component signal transduction Podgornaia, Anna Igorevna Laub, Michael T Massachusetts Institute of Technology. Computational and Systems Biology Program Massachusetts Institute of Technology. Department of Biology Laub, Michael T. Podgornaia, Anna Igorevna Laub, Michael T. Maintaining the faithful flow of information through signal transduction pathways is critical to the survival and proliferation of organisms. This problem is particularly challenging as many signaling proteins are part of large, paralogous families that are highly similar at the sequence and structural levels, increasing the risk of unwanted cross-talk. To detect environmental signals and process information, bacteria rely heavily on two-component signaling systems comprised of sensor histidine kinases and their cognate response regulators. Although most species encode dozens of these signaling pathways, there is relatively little cross-talk, indicating that individual pathways are well insulated and highly specific. Here, we review the molecular mechanisms that enforce this specificity. Further, we highlight recent studies that have revealed how these mechanisms evolve to accommodate the introduction of new pathways by gene duplication. Howard Hughes Medical Institute (Early Career Scientist) National Science Foundation (U.S.) (NSF CAREER award (MCB-0844442)) National Science Foundation (U.S.) (NSF Graduate Research Fellowship) 2016-08-29T16:28:20Z 2016-08-29T16:28:20Z 2013-01 Article http://purl.org/eprint/type/JournalArticle 13695274 http://hdl.handle.net/1721.1/104060 Podgornaia, Anna I., and Michael T. Laub. “Determinants of Specificity in Two-Component Signal Transduction.” Current Opinion in Microbiology 16, no. 2 (April 2013): 156-162. https://orcid.org/0000-0002-8288-7607 en_US http://dx.doi.org/10.1016/j.mib.2013.01.004 Current Opinion in Microbiology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier Prof. Laub via Courtney Crummett |
| spellingShingle | Podgornaia, Anna Igorevna Laub, Michael T Determinants of specificity in two-component signal transduction |
| title | Determinants of specificity in two-component signal transduction |
| title_full | Determinants of specificity in two-component signal transduction |
| title_fullStr | Determinants of specificity in two-component signal transduction |
| title_full_unstemmed | Determinants of specificity in two-component signal transduction |
| title_short | Determinants of specificity in two-component signal transduction |
| title_sort | determinants of specificity in two component signal transduction |
| url | http://hdl.handle.net/1721.1/104060 https://orcid.org/0000-0002-8288-7607 |
| work_keys_str_mv | AT podgornaiaannaigorevna determinantsofspecificityintwocomponentsignaltransduction AT laubmichaelt determinantsofspecificityintwocomponentsignaltransduction |