SIRT1 and other sirtuins in metabolism
Available in PMC 2015 March 01.
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/104067 https://orcid.org/0000-0003-4064-2510 |
| _version_ | 1826198438521339904 |
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| author | Chang, Hung-Chun Guarente, Leonard Pershing |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Chang, Hung-Chun Guarente, Leonard Pershing |
| author_sort | Chang, Hung-Chun |
| collection | MIT |
| description | Available in PMC 2015 March 01. |
| first_indexed | 2024-09-23T11:04:57Z |
| format | Article |
| id | mit-1721.1/104067 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:04:57Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1040672022-10-01T01:05:01Z SIRT1 and other sirtuins in metabolism Chang, Hung-Chun Guarente, Leonard Pershing Massachusetts Institute of Technology. Department of Biology Paul F. Glenn Center for Biology of Aging Research (Massachusetts Institute of Technology) Koch Institute for Integrative Cancer Research at MIT Chang, Hung-Chun Guarente, Leonard Pershing Available in PMC 2015 March 01. Sirtuins such as SIRT1 are conserved protein NAD[superscript +]-dependent deacylases and thus their function is intrinsically linked to cellular metabolism. Over the past two decades, accumulating evidence has indicated that sirtuins are not only important energy status sensors but also protect cells against metabolic stresses. Sirtuins regulate the aging process and are themselves regulated by diet and environmental stress. The versatile functions of sirtuins including, more specifically, SIRT1 are supported by their diverse cellular location allowing cells to sense changes in energy levels in the nucleus, cytoplasm, and mitochondrion. SIRT1 plays a critical role in metabolic health by deacetylating many target proteins in numerous tissues, including liver, muscle, adipose tissue, heart, and endothelium. This sirtuin also exerts important systemic effects via the hypothalamus. This review will cover these topics and suggest that strategies to maintain sirtuin activity may be on the horizon to forestall diseases of aging. National Institutes of Health (U.S.) Life Sciences Research Foundation (Ellison Medical Foundation Fellow) Glenn Foundation for Medical Research 2016-08-30T17:39:30Z 2016-08-30T17:39:30Z 2014-03 Article http://purl.org/eprint/type/JournalArticle 10432760 http://hdl.handle.net/1721.1/104067 Chang, Hung-Chun, and Leonard Guarente. “SIRT1 and Other Sirtuins in Metabolism.” Trends in Endocrinology & Metabolism 25, no. 3 (March 2014): 138-145. https://orcid.org/0000-0003-4064-2510 en_US http://dx.doi.org/10.1016/j.tem.2013.12.001 Trends in Endocrinology & Metabolism Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Chang, Hung-Chun Guarente, Leonard Pershing SIRT1 and other sirtuins in metabolism |
| title | SIRT1 and other sirtuins in metabolism |
| title_full | SIRT1 and other sirtuins in metabolism |
| title_fullStr | SIRT1 and other sirtuins in metabolism |
| title_full_unstemmed | SIRT1 and other sirtuins in metabolism |
| title_short | SIRT1 and other sirtuins in metabolism |
| title_sort | sirt1 and other sirtuins in metabolism |
| url | http://hdl.handle.net/1721.1/104067 https://orcid.org/0000-0003-4064-2510 |
| work_keys_str_mv | AT changhungchun sirt1andothersirtuinsinmetabolism AT guarenteleonardpershing sirt1andothersirtuinsinmetabolism |