A Perspective on the Clinical Translation of Scaffolds for Tissue Engineering
Scaffolds have been broadly applied within tissue engineering and regenerative medicine to regenerate, replace, or augment diseased or damaged tissue. For a scaffold to perform optimally, several design considerations must be addressed, with an eye toward the eventual form, function, and tissue site...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Springer US
2016
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| Online Access: | http://hdl.handle.net/1721.1/104085 https://orcid.org/0000-0003-3811-2369 https://orcid.org/0000-0003-0624-3532 https://orcid.org/0000-0003-4255-0492 |
| _version_ | 1811088496981442560 |
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| author | Tang, Benjamin C. Webber, Matthew Langer, Robert S Khan, Omar Fizal Sydlik, Stefanie Arlene |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Tang, Benjamin C. Webber, Matthew Langer, Robert S Khan, Omar Fizal Sydlik, Stefanie Arlene |
| author_sort | Tang, Benjamin C. |
| collection | MIT |
| description | Scaffolds have been broadly applied within tissue engineering and regenerative medicine to regenerate, replace, or augment diseased or damaged tissue. For a scaffold to perform optimally, several design considerations must be addressed, with an eye toward the eventual form, function, and tissue site. The chemical and mechanical properties of the scaffold must be tuned to optimize the interaction with cells and surrounding tissues. For complex tissue engineering, mass transport limitations, vascularization, and host tissue integration are important considerations. As the tissue architecture to be replaced becomes more complex and hierarchical, scaffold design must also match this complexity to recapitulate a functioning tissue. We outline these design constraints and highlight creative and emerging strategies to overcome limitations and modulate scaffold properties for optimal regeneration. We also highlight some of the most advanced strategies that have seen clinical application and discuss the hurdles that must be overcome for clinical use and commercialization of tissue engineering technologies. Finally, we provide a perspective on the future of scaffolds as a functional contributor to advancing tissue engineering and regenerative medicine. |
| first_indexed | 2024-09-23T14:03:05Z |
| format | Article |
| id | mit-1721.1/104085 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:03:05Z |
| publishDate | 2016 |
| publisher | Springer US |
| record_format | dspace |
| spelling | mit-1721.1/1040852022-09-28T18:00:18Z A Perspective on the Clinical Translation of Scaffolds for Tissue Engineering Tang, Benjamin C. Webber, Matthew Langer, Robert S Khan, Omar Fizal Sydlik, Stefanie Arlene Massachusetts Institute of Technology. Institute for Medical Engineering & Science Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT Webber, Matthew Langer, Robert Khan, Omar F. Sydlik, Stefanie A. Tang, Benjamin C. Scaffolds have been broadly applied within tissue engineering and regenerative medicine to regenerate, replace, or augment diseased or damaged tissue. For a scaffold to perform optimally, several design considerations must be addressed, with an eye toward the eventual form, function, and tissue site. The chemical and mechanical properties of the scaffold must be tuned to optimize the interaction with cells and surrounding tissues. For complex tissue engineering, mass transport limitations, vascularization, and host tissue integration are important considerations. As the tissue architecture to be replaced becomes more complex and hierarchical, scaffold design must also match this complexity to recapitulate a functioning tissue. We outline these design constraints and highlight creative and emerging strategies to overcome limitations and modulate scaffold properties for optimal regeneration. We also highlight some of the most advanced strategies that have seen clinical application and discuss the hurdles that must be overcome for clinical use and commercialization of tissue engineering technologies. Finally, we provide a perspective on the future of scaffolds as a functional contributor to advancing tissue engineering and regenerative medicine. National Institutes of Health (U.S.) (Ruth Kirschstein National Research Service Award (F32DK101335)) Juvenile Diabetes Research Foundation International (a Postdoctoral Fellowship (3-2011-310)) 2016-08-30T21:40:58Z 2016-08-30T21:40:58Z 2014-09 2014-07 2016-05-23T12:16:39Z Article http://purl.org/eprint/type/JournalArticle 0090-6964 1573-9686 http://hdl.handle.net/1721.1/104085 Webber, Matthew J., Omar F. Khan, Stefanie A. Sydlik, Benjamin C. Tang, and Robert Langer. “A Perspective on the Clinical Translation of Scaffolds for Tissue Engineering.” Ann Biomed Eng 43, no. 3 (September 9, 2014): 641–656. https://orcid.org/0000-0003-3811-2369 https://orcid.org/0000-0003-0624-3532 https://orcid.org/0000-0003-4255-0492 en http://dx.doi.org/10.1007/s10439-014-1104-7 Annals of Biomedical Engineering Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ Biomedical Engineering Society application/pdf Springer US Springer US |
| spellingShingle | Tang, Benjamin C. Webber, Matthew Langer, Robert S Khan, Omar Fizal Sydlik, Stefanie Arlene A Perspective on the Clinical Translation of Scaffolds for Tissue Engineering |
| title | A Perspective on the Clinical Translation of Scaffolds for Tissue Engineering |
| title_full | A Perspective on the Clinical Translation of Scaffolds for Tissue Engineering |
| title_fullStr | A Perspective on the Clinical Translation of Scaffolds for Tissue Engineering |
| title_full_unstemmed | A Perspective on the Clinical Translation of Scaffolds for Tissue Engineering |
| title_short | A Perspective on the Clinical Translation of Scaffolds for Tissue Engineering |
| title_sort | perspective on the clinical translation of scaffolds for tissue engineering |
| url | http://hdl.handle.net/1721.1/104085 https://orcid.org/0000-0003-3811-2369 https://orcid.org/0000-0003-0624-3532 https://orcid.org/0000-0003-4255-0492 |
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