Molecular Control of Induced Pluripotency
Deciphering the mechanisms of epigenetic reprogramming provides fundamental insights into cell fate decisions, which in turn reveal strategies to make the reprogramming process increasingly efficient. Here we review recent advances in epigenetic reprogramming to pluripotency with a focus on the prin...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/104363 |
| _version_ | 1811073036189696000 |
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| author | Theunissen, Thorold W. Jaenisch, Rudolf |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Theunissen, Thorold W. Jaenisch, Rudolf |
| author_sort | Theunissen, Thorold W. |
| collection | MIT |
| description | Deciphering the mechanisms of epigenetic reprogramming provides fundamental insights into cell fate decisions, which in turn reveal strategies to make the reprogramming process increasingly efficient. Here we review recent advances in epigenetic reprogramming to pluripotency with a focus on the principal molecular regulators. We examine the trajectories connecting somatic and pluripotent cells, genetic and chemical methodologies for inducing pluripotency, the role of endogenous master transcription factors in establishing the pluripotent state, and functional interactions between reprogramming factors and epigenetic regulators. Defining the crosstalk among the diverse molecular actors implicated in cellular reprogramming presents a major challenge for future inquiry. |
| first_indexed | 2024-09-23T09:27:36Z |
| format | Article |
| id | mit-1721.1/104363 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:27:36Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1043632022-09-30T14:31:52Z Molecular Control of Induced Pluripotency Theunissen, Thorold W. Jaenisch, Rudolf Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Jaenisch, Rudolf Deciphering the mechanisms of epigenetic reprogramming provides fundamental insights into cell fate decisions, which in turn reveal strategies to make the reprogramming process increasingly efficient. Here we review recent advances in epigenetic reprogramming to pluripotency with a focus on the principal molecular regulators. We examine the trajectories connecting somatic and pluripotent cells, genetic and chemical methodologies for inducing pluripotency, the role of endogenous master transcription factors in establishing the pluripotent state, and functional interactions between reprogramming factors and epigenetic regulators. Defining the crosstalk among the diverse molecular actors implicated in cellular reprogramming presents a major challenge for future inquiry. Wellcome Trust (London, England) (Henry Wellcome Postdoctoral Fellowship) 2016-09-21T19:46:28Z 2016-09-21T19:46:28Z 2014-06 Article http://purl.org/eprint/type/JournalArticle 19345909 http://hdl.handle.net/1721.1/104363 Theunissen, Thorold W., and Rudolf Jaenisch. “Molecular Control of Induced Pluripotency.” Cell Stem Cell 14, no. 6 (June 2014): 720-734. en_US http://dx.doi.org/10.1016/j.stem.2014.05.002 Cell Stem Cell Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Theunissen, Thorold W. Jaenisch, Rudolf Molecular Control of Induced Pluripotency |
| title | Molecular Control of Induced Pluripotency |
| title_full | Molecular Control of Induced Pluripotency |
| title_fullStr | Molecular Control of Induced Pluripotency |
| title_full_unstemmed | Molecular Control of Induced Pluripotency |
| title_short | Molecular Control of Induced Pluripotency |
| title_sort | molecular control of induced pluripotency |
| url | http://hdl.handle.net/1721.1/104363 |
| work_keys_str_mv | AT theunissenthoroldw molecularcontrolofinducedpluripotency AT jaenischrudolf molecularcontrolofinducedpluripotency |