Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity [superscript 86]Y- or [superscipt 177]Lu-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates
Purpose: GPA33 is a colorectal cancer (CRC) antigen with unique retention properties after huA33-mediated tumor targeting. We tested a pretargeted radioimmunotherapy (PRIT) approach for CRC using a tetravalent bispecific antibody with dual specificity for GPA33 tumor antigen and DOTA-Bn–(radiolantha...
Main Authors: | Xu, Hong, Guo, Hong-fen, Lee, Sang-gyu, Punzalan, Blesida, Chalasani, Sandhya, Jungbluth, Achim, O’Donoghue, Joseph, Cheal, Sarah M., Fung, Edward K., Zanzonico, Pat B., Carrasquillo, Jorge A., Smith-Jones, Peter M., Cheung, Nai-Kong V., Larson, Steven M., Wittrup, Karl Dane |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Language: | English |
Published: |
Springer Berlin Heidelberg
2016
|
Online Access: | http://hdl.handle.net/1721.1/104432 |
Similar Items
-
Improved mehtods and reagents for pretargeted radioimmunotherapy of cancer
by: Zajic, Stefan C
Published: (2007) -
Preparation and preclinical evaluation of humanised A33 immunoconjugates for radioimmunotherapy.
by: King, D, et al.
Published: (1995) -
Modified poly-L-lysine for use as a clearing agent in pretargeted radioimmunotherapy
by: Chiara Timperanza, et al.
Published: (2024-11-01) -
Synthesis and In Vitro Comparison of DOTA, NODAGA and 15-5 Macrocycles as Chelators for the <sup>64</sup>Cu-Labelling of Immunoconjugates
by: Aurélie Maisonial-Besset, et al.
Published: (2022-12-01) -
Development of [225Ac]Ac-DOTA-C595 as radioimmunotherapy of pancreatic cancer: in vitro evaluation, dosimetric assessment and detector calibration
by: Ashleigh Hull, et al.
Published: (2023-09-01)