Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity [superscript 86]Y- or [superscipt 177]Lu-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates

Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity [superscript 86]Y- or [superscipt 177]Lu-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates

Purpose: GPA33 is a colorectal cancer (CRC) antigen with unique retention properties after huA33-mediated tumor targeting. We tested a pretargeted radioimmunotherapy (PRIT) approach for CRC using a tetravalent bispecific antibody with dual specificity for GPA33 tumor antigen and DOTA-Bn–(radiolantha...

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Bibliographic Details
Main Authors: Xu, Hong, Guo, Hong-fen, Lee, Sang-gyu, Punzalan, Blesida, Chalasani, Sandhya, Jungbluth, Achim, O’Donoghue, Joseph, Cheal, Sarah M., Fung, Edward K., Zanzonico, Pat B., Carrasquillo, Jorge A., Smith-Jones, Peter M., Cheung, Nai-Kong V., Larson, Steven M., Wittrup, Karl Dane
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Springer Berlin Heidelberg 2016
Online Access:http://hdl.handle.net/1721.1/104432

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