Enzyme-Catalyzed Macrocyclization of Long Unprotected Peptides
A glutathione S-transferase (GST) catalyzed macrocyclization reaction for peptides up to 40 amino acids in length is reported. GST catalyzes the selective SNAr reaction between an N-terminal glutathione (GSH, γ-Glu-Cys-Gly) tag and a C-terminal perfluoroaryl-modified cysteine on the same polypeptide...
Main Authors: | Zhang, Chi, Dai, Peng, Spokoyny, Alexander M., Pentelute, Bradley L. |
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Other Authors: | Massachusetts Institute of Technology. Department of Chemistry |
Format: | Article |
Language: | en_US |
Published: |
American Chemical Society (ACS)
2016
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Online Access: | http://hdl.handle.net/1721.1/104805 https://orcid.org/0000-0002-5253-6873 https://orcid.org/0000-0002-4581-3473 |
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