Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols
Purpose: There is a large body of evidence supporting the efficacy of low-level laser therapy (LLLT), more recently termed photobiomodulation (PBM) for the management of oral mucositis (OM) in patients undergoing radiotherapy for head and neck cancer (HNC). Recent advances in PBM technology, togethe...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer-Verlag
2016
|
| Online Access: | http://hdl.handle.net/1721.1/104862 |
| _version_ | 1826192554569236480 |
|---|---|
| author | Elad, Sharon Barasch, Andrei Genot, Marie-Thérèse Lansaat, Liset van der Brink, Ron Arnabat-Dominguez, Josep van der Molen, Lisette Jacobi, Irene van Diessen, Judi de Lange, Jan Bensadoun, René-Jean Zecha, Judith A. E. M. Raber-Durlacher, Judith E. Nair, Raj G. Epstein, Joel B. Migliorati, Cesar A. Milstein, Dan M. J. Smeele, Ludi E. Schubert, Mark M. Hamblin, Michael R |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Elad, Sharon Barasch, Andrei Genot, Marie-Thérèse Lansaat, Liset van der Brink, Ron Arnabat-Dominguez, Josep van der Molen, Lisette Jacobi, Irene van Diessen, Judi de Lange, Jan Bensadoun, René-Jean Zecha, Judith A. E. M. Raber-Durlacher, Judith E. Nair, Raj G. Epstein, Joel B. Migliorati, Cesar A. Milstein, Dan M. J. Smeele, Ludi E. Schubert, Mark M. Hamblin, Michael R |
| author_sort | Elad, Sharon |
| collection | MIT |
| description | Purpose: There is a large body of evidence supporting the efficacy of low-level laser therapy (LLLT), more recently termed photobiomodulation (PBM) for the management of oral mucositis (OM) in patients undergoing radiotherapy for head and neck cancer (HNC). Recent advances in PBM technology, together with a better understanding of mechanisms involved and dosimetric parameters may lead to the management of a broader range of complications associated with HNC treatment. This could enhance patient adherence to cancer therapy, and improve quality of life and treatment outcomes. The mechanisms of action, dosimetric, and safety considerations for PBM have been reviewed in part 1. Part 2 discusses the head and neck treatment side effects for which PBM may prove to be effective. In addition, PBM parameters for each of these complications are suggested and future research directions are discussed.
Methods: Narrative review and presentation of PBM parameters are based on current evidence and expert opinion.
Results: PBM may have potential applications in the management of a broad range of side effects of (chemo)radiation therapy (CRT) in patients being treated for HNC. For OM management, optimal PBM parameters identified were as follows: wavelength, typically between 633 and 685 nm or 780–830 nm; energy density, laser or light-emitting diode (LED) output between 10 and 150 mW; dose, 2–3 J (J/cm2), and no more than 6 J/cm2 on the tissue surface treated; treatment schedule, two to three times a week up to daily; emission type, pulsed (<100 Hz); and route of delivery, intraorally and/or transcutaneously. To facilitate further studies, we propose potentially effective PBM parameters for prophylactic and therapeutic use in supportive care for dermatitis, dysphagia, dry mouth, dysgeusia, trismus, necrosis, lymphedema, and voice/speech alterations.
Conclusion: PBM may have a role in supportive care for a broad range of complications associated with the treatment of HNC with CRT. The suggested PBM irradiation and dosimetric parameters, which are potentially effective for these complications, are intended to provide guidance for well-designed future studies. It is imperative that such studies include elucidating the effects of PBM on oncology treatment outcomes. |
| first_indexed | 2024-09-23T09:21:04Z |
| format | Article |
| id | mit-1721.1/104862 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:21:04Z |
| publishDate | 2016 |
| publisher | Springer-Verlag |
| record_format | dspace |
| spelling | mit-1721.1/1048622022-09-30T14:17:59Z Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols Elad, Sharon Barasch, Andrei Genot, Marie-Thérèse Lansaat, Liset van der Brink, Ron Arnabat-Dominguez, Josep van der Molen, Lisette Jacobi, Irene van Diessen, Judi de Lange, Jan Bensadoun, René-Jean Zecha, Judith A. E. M. Raber-Durlacher, Judith E. Nair, Raj G. Epstein, Joel B. Migliorati, Cesar A. Milstein, Dan M. J. Smeele, Ludi E. Schubert, Mark M. Hamblin, Michael R Harvard University--MIT Division of Health Sciences and Technology Hamblin, Michael R Purpose: There is a large body of evidence supporting the efficacy of low-level laser therapy (LLLT), more recently termed photobiomodulation (PBM) for the management of oral mucositis (OM) in patients undergoing radiotherapy for head and neck cancer (HNC). Recent advances in PBM technology, together with a better understanding of mechanisms involved and dosimetric parameters may lead to the management of a broader range of complications associated with HNC treatment. This could enhance patient adherence to cancer therapy, and improve quality of life and treatment outcomes. The mechanisms of action, dosimetric, and safety considerations for PBM have been reviewed in part 1. Part 2 discusses the head and neck treatment side effects for which PBM may prove to be effective. In addition, PBM parameters for each of these complications are suggested and future research directions are discussed. Methods: Narrative review and presentation of PBM parameters are based on current evidence and expert opinion. Results: PBM may have potential applications in the management of a broad range of side effects of (chemo)radiation therapy (CRT) in patients being treated for HNC. For OM management, optimal PBM parameters identified were as follows: wavelength, typically between 633 and 685 nm or 780–830 nm; energy density, laser or light-emitting diode (LED) output between 10 and 150 mW; dose, 2–3 J (J/cm2), and no more than 6 J/cm2 on the tissue surface treated; treatment schedule, two to three times a week up to daily; emission type, pulsed (<100 Hz); and route of delivery, intraorally and/or transcutaneously. To facilitate further studies, we propose potentially effective PBM parameters for prophylactic and therapeutic use in supportive care for dermatitis, dysphagia, dry mouth, dysgeusia, trismus, necrosis, lymphedema, and voice/speech alterations. Conclusion: PBM may have a role in supportive care for a broad range of complications associated with the treatment of HNC with CRT. The suggested PBM irradiation and dosimetric parameters, which are potentially effective for these complications, are intended to provide guidance for well-designed future studies. It is imperative that such studies include elucidating the effects of PBM on oncology treatment outcomes. National Institutes of Health (U.S.) (NIH grant R01AI050875) 2016-10-19T19:17:05Z 2017-03-01T16:14:48Z 2016-03 2015-08 2016-08-18T15:28:21Z Article http://purl.org/eprint/type/JournalArticle 0941-4355 1433-7339 http://hdl.handle.net/1721.1/104862 Zecha, Judith A. E. M., Judith E. Raber-Durlacher, Raj G. Nair, Joel B. Epstein, Sharon Elad, Michael R. Hamblin, Andrei Barasch, et al. “Low-Level Laser Therapy/photobiomodulation in the Management of Side Effects of Chemoradiation Therapy in Head and Neck Cancer: Part 2: Proposed Applications and Treatment Protocols.” Supportive Care in Cancer, vol. 24, no. 6 (March 2016), pp. 2793–2805. en http://dx.doi.org/10.1007/s00520-016-3153-y Supportive Care in Cancer Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. Springer-Verlag Berlin Heidelberg application/pdf Springer-Verlag Springer Berlin Heidelberg |
| spellingShingle | Elad, Sharon Barasch, Andrei Genot, Marie-Thérèse Lansaat, Liset van der Brink, Ron Arnabat-Dominguez, Josep van der Molen, Lisette Jacobi, Irene van Diessen, Judi de Lange, Jan Bensadoun, René-Jean Zecha, Judith A. E. M. Raber-Durlacher, Judith E. Nair, Raj G. Epstein, Joel B. Migliorati, Cesar A. Milstein, Dan M. J. Smeele, Ludi E. Schubert, Mark M. Hamblin, Michael R Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols |
| title | Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols |
| title_full | Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols |
| title_fullStr | Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols |
| title_full_unstemmed | Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols |
| title_short | Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols |
| title_sort | low level laser therapy photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer part 2 proposed applications and treatment protocols |
| url | http://hdl.handle.net/1721.1/104862 |
| work_keys_str_mv | AT eladsharon lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT baraschandrei lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT genotmarietherese lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT lansaatliset lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT vanderbrinkron lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT arnabatdominguezjosep lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT vandermolenlisette lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT jacobiirene lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT vandiessenjudi lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT delangejan lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT bensadounrenejean lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT zechajudithaem lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT raberdurlacherjudithe lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT nairrajg lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT epsteinjoelb lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT miglioraticesara lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT milsteindanmj lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT smeeleludie lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT schubertmarkm lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols AT hamblinmichaelr lowlevellasertherapyphotobiomodulationinthemanagementofsideeffectsofchemoradiationtherapyinheadandneckcancerpart2proposedapplicationsandtreatmentprotocols |