Proteolysis triggers self-assembly and unmasks innate immune function of a human α-defensin peptide
Human α-defensin 6 (HD6) is a unique peptide of the defensin family that provides innate immunity in the intestine by self-assembling to form higher-order oligomers that entrap bacteria and prevent host cell invasion. Here, we report critical steps in the self-assembly pathway of HD6. We demonstrate...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Royal Society of Chemistry (RCS)
2016
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| Online Access: | http://hdl.handle.net/1721.1/104963 https://orcid.org/0000-0002-5356-3638 https://orcid.org/0000-0002-6153-8803 |