Visualizing the Choriocapillaris Under Drusen: Comparing 1050-nm Swept-Source Versus 840-nm Spectral-Domain Optical Coherence Tomography Angiography
Purpose: To investigate the appearance of choriocapillaris (CC) flow under drusen by comparing long-wavelength (1050 nm) swept-source optical coherence tomography (SS-OCT) angiography with shorter-wavelength (840 nm) spectral-domain (SD) OCT angiography. Methods: Patients with drusen imaged on bo...
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| Format: | Article |
| Language: | en_US |
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Association for Research in Vision and Ophthalmology (ARVO)
2016
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| Online Access: | http://hdl.handle.net/1721.1/105159 https://orcid.org/0000-0003-3859-3094 https://orcid.org/0000-0002-0828-4357 |
| _version_ | 1826193769355018240 |
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| author | Lane, Mark Novais, Eduardo A. Louzada, Ricardo N. Cole, Emily D. Lee, ByungKun Keane, Pearse A. Denniston, Alastair K. Witkin, André J. Baumal, Caroline R. Duker, Jay S. Waheed, Nadia K. Moult, Eric Michael Husvogt, Lennart Fujimoto, James G |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Lane, Mark Novais, Eduardo A. Louzada, Ricardo N. Cole, Emily D. Lee, ByungKun Keane, Pearse A. Denniston, Alastair K. Witkin, André J. Baumal, Caroline R. Duker, Jay S. Waheed, Nadia K. Moult, Eric Michael Husvogt, Lennart Fujimoto, James G |
| author_sort | Lane, Mark |
| collection | MIT |
| description | Purpose: To investigate the appearance of choriocapillaris (CC) flow under drusen by comparing long-wavelength (1050 nm) swept-source optical coherence tomography (SS-OCT) angiography with shorter-wavelength (840 nm) spectral-domain (SD) OCT angiography.
Methods: Patients with drusen imaged on both devices on the same day were selected and graded. Ambiguous OCT angiography (OCTA) signal loss was defined as low OCTA signal on the en face OCTA CC image that also had low OCT signal in the corresponding area on the en face OCT CC image and OCT B-scans. Unambiguous OCTA signal loss was defined as low OCTA signal on the en face OCTA CC image that did not have low OCT signal in the corresponding area on the en face OCT CC image and OCT B-scans. False-positive flow impairment on SS-OCTA was defined as ambiguous OCTA signal loss on SS-OCTA but no OCTA signal loss on SD-OCTA. False-positive flow impairment on SD-OCTA was defined as ambiguous OCTA signal loss on SD-OCTA but no OCTA signal loss on SS-OCTA.
Results: Nine eyes from seven patients were enrolled, 23 drusen were analyzed. On 840-nm SD-OCTA, 17 drusen (73.9%) exhibited OCTA signal loss. Fourteen (82.4%) were classified as ambiguous, and three (17.6%) were classified as unambiguous; 10 (58.8%) were classified as having false-positive flow impairment. On 1050-nm SS-OCTA, seven drusen (30.4%) exhibited OCTA signal loss and were classified as unambiguous; none were classified as having false-positive flow impairment.
Conclusions: Results showed that 1050-nm SS-OCTA appears less prone to producing areas of false-positive flow impairment under drusen. |
| first_indexed | 2024-09-23T09:44:36Z |
| format | Article |
| id | mit-1721.1/105159 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:44:36Z |
| publishDate | 2016 |
| publisher | Association for Research in Vision and Ophthalmology (ARVO) |
| record_format | dspace |
| spelling | mit-1721.1/1051592022-09-30T16:36:58Z Visualizing the Choriocapillaris Under Drusen: Comparing 1050-nm Swept-Source Versus 840-nm Spectral-Domain Optical Coherence Tomography Angiography Lane, Mark Novais, Eduardo A. Louzada, Ricardo N. Cole, Emily D. Lee, ByungKun Keane, Pearse A. Denniston, Alastair K. Witkin, André J. Baumal, Caroline R. Duker, Jay S. Waheed, Nadia K. Moult, Eric Michael Husvogt, Lennart Fujimoto, James G Massachusetts Institute of Technology. Institute for Medical Engineering & Science Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Moult, Eric Michael Husvogt, Lennart Fujimoto, James G Purpose: To investigate the appearance of choriocapillaris (CC) flow under drusen by comparing long-wavelength (1050 nm) swept-source optical coherence tomography (SS-OCT) angiography with shorter-wavelength (840 nm) spectral-domain (SD) OCT angiography. Methods: Patients with drusen imaged on both devices on the same day were selected and graded. Ambiguous OCT angiography (OCTA) signal loss was defined as low OCTA signal on the en face OCTA CC image that also had low OCT signal in the corresponding area on the en face OCT CC image and OCT B-scans. Unambiguous OCTA signal loss was defined as low OCTA signal on the en face OCTA CC image that did not have low OCT signal in the corresponding area on the en face OCT CC image and OCT B-scans. False-positive flow impairment on SS-OCTA was defined as ambiguous OCTA signal loss on SS-OCTA but no OCTA signal loss on SD-OCTA. False-positive flow impairment on SD-OCTA was defined as ambiguous OCTA signal loss on SD-OCTA but no OCTA signal loss on SS-OCTA. Results: Nine eyes from seven patients were enrolled, 23 drusen were analyzed. On 840-nm SD-OCTA, 17 drusen (73.9%) exhibited OCTA signal loss. Fourteen (82.4%) were classified as ambiguous, and three (17.6%) were classified as unambiguous; 10 (58.8%) were classified as having false-positive flow impairment. On 1050-nm SS-OCTA, seven drusen (30.4%) exhibited OCTA signal loss and were classified as unambiguous; none were classified as having false-positive flow impairment. Conclusions: Results showed that 1050-nm SS-OCTA appears less prone to producing areas of false-positive flow impairment under drusen. Macula Vision Research Foundation National Institutes of Health (U.S.) (NIH R01-EY011289-30) National Institutes of Health (U.S.) (R44-EY022864-03) National Institutes of Health (U.S.) (R01-CA075289-19) United States. Air Force Office of Scientific Research (AFOSR FA9550-15-1-0473) United States. Air Force Office of Scientific Research (AFA9550-12-1-0499) Champalimaud Foundation Massachusetts Lions Club Birdshot Uveitis Society/Fight for Sight (24BU151) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Brazil. Ministry of Education 2016-11-01T15:09:31Z 2016-11-01T15:09:31Z 2016-08 2015-12 Article http://purl.org/eprint/type/JournalArticle 1552-5783 0146-0404 http://hdl.handle.net/1721.1/105159 Lane, Mark, Eric M. Moult, Eduardo A. Novais, Ricardo N. Louzada, Emily D. Cole, ByungKun Lee, Lennart Husvogt, et al. “Visualizing the Choriocapillaris Under Drusen: Comparing 1050-Nm Swept-Source Versus 840-Nm Spectral-Domain Optical Coherence Tomography Angiography.” Invest. Ophthalmol. Vis. Sci. 57, no. 9 (August 17, 2016): OCT585. https://orcid.org/0000-0003-3859-3094 https://orcid.org/0000-0002-0828-4357 en_US http://dx.doi.org/10.1167/iovs.15-18915 Investigative Opthalmology & Visual Science Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Association for Research in Vision and Ophthalmology (ARVO) Association for Research in Vision and Ophthalmology (ARVO) |
| spellingShingle | Lane, Mark Novais, Eduardo A. Louzada, Ricardo N. Cole, Emily D. Lee, ByungKun Keane, Pearse A. Denniston, Alastair K. Witkin, André J. Baumal, Caroline R. Duker, Jay S. Waheed, Nadia K. Moult, Eric Michael Husvogt, Lennart Fujimoto, James G Visualizing the Choriocapillaris Under Drusen: Comparing 1050-nm Swept-Source Versus 840-nm Spectral-Domain Optical Coherence Tomography Angiography |
| title | Visualizing the Choriocapillaris Under Drusen: Comparing 1050-nm Swept-Source Versus 840-nm Spectral-Domain Optical Coherence Tomography Angiography |
| title_full | Visualizing the Choriocapillaris Under Drusen: Comparing 1050-nm Swept-Source Versus 840-nm Spectral-Domain Optical Coherence Tomography Angiography |
| title_fullStr | Visualizing the Choriocapillaris Under Drusen: Comparing 1050-nm Swept-Source Versus 840-nm Spectral-Domain Optical Coherence Tomography Angiography |
| title_full_unstemmed | Visualizing the Choriocapillaris Under Drusen: Comparing 1050-nm Swept-Source Versus 840-nm Spectral-Domain Optical Coherence Tomography Angiography |
| title_short | Visualizing the Choriocapillaris Under Drusen: Comparing 1050-nm Swept-Source Versus 840-nm Spectral-Domain Optical Coherence Tomography Angiography |
| title_sort | visualizing the choriocapillaris under drusen comparing 1050 nm swept source versus 840 nm spectral domain optical coherence tomography angiography |
| url | http://hdl.handle.net/1721.1/105159 https://orcid.org/0000-0003-3859-3094 https://orcid.org/0000-0002-0828-4357 |
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