Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE

Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE

Cancer invasion is a hallmark of metastasis. The mesenchymal mode of cancer cell invasion is mediated by elongated membrane protrusions driven by the assembly of branched F-actin networks. How deregulation of actin regulators promotes cancer cell invasion is still enigmatic. We report that increased...

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Bibliographic Details
Main Authors: Perera, U., Gillett, C., Law, A-L., Sharma, V. P., Wang, J., Mosis, F., De Piano, M., Monypenny, J., Woodman, N., Mouneimne, G., Van Hemelrijck, M., Cao, Y., Condeelis, J., Krause, M., Carmona, Guillaume, Naba, Alexandra, Wyckoff, Jeffrey, Balsamo, Michele, McConnell, Russell E., Hynes, Richard O., Gertler, Frank
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Springer Nature 2016
Online Access:http://hdl.handle.net/1721.1/105260
https://orcid.org/0000-0001-5063-8502
https://orcid.org/0000-0001-7603-8396
https://orcid.org/0000-0003-3214-4554

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