3D Bioprinting for Tissue and Organ Fabrication
The field of regenerative medicine has progressed tremendously over the past few decades in its ability to fabricate functional tissue substitutes. Conventional approaches based on scaffolding and microengineering are limited in their capacity of producing tissue constructs with precise biomimetic p...
| Main Authors: | , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Springer US
2016
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| Online Access: | http://hdl.handle.net/1721.1/105262 |
| _version_ | 1811088626206900224 |
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| author | Oklu, Rahmi Zhang, Yu Shrike Yue, Kan Aleman, Julio Mollazadeh-Moghaddam, Kamyar Bakht, Syeda Mahwish Yang, Jingzhou Jia, Weitao Dell’Erba, Valeria Assawes, Pribpandao Shin, Su Ryon Dokmeci, Mehmet R. Khademhosseini, Alireza |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Oklu, Rahmi Zhang, Yu Shrike Yue, Kan Aleman, Julio Mollazadeh-Moghaddam, Kamyar Bakht, Syeda Mahwish Yang, Jingzhou Jia, Weitao Dell’Erba, Valeria Assawes, Pribpandao Shin, Su Ryon Dokmeci, Mehmet R. Khademhosseini, Alireza |
| author_sort | Oklu, Rahmi |
| collection | MIT |
| description | The field of regenerative medicine has progressed tremendously over the past few decades in its ability to fabricate functional tissue substitutes. Conventional approaches based on scaffolding and microengineering are limited in their capacity of producing tissue constructs with precise biomimetic properties. Three-dimensional (3D) bioprinting technology, on the other hand, promises to bridge the divergence between artificially engineered tissue constructs and native tissues. In a sense, 3D bioprinting offers unprecedented versatility to co-deliver cells and biomaterials with precise control over their compositions, spatial distributions, and architectural accuracy, therefore achieving detailed or even personalized recapitulation of the fine shape, structure, and architecture of target tissues and organs. Here we briefly describe recent progresses of 3D bioprinting technology and associated bioinks suitable for the printing process. We then focus on the applications of this technology in fabrication of biomimetic constructs of several representative tissues and organs, including blood vessel, heart, liver, and cartilage. We finally conclude with future challenges in 3D bioprinting as well as potential solutions for further development. |
| first_indexed | 2024-09-23T14:04:58Z |
| format | Article |
| id | mit-1721.1/105262 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:04:58Z |
| publishDate | 2016 |
| publisher | Springer US |
| record_format | dspace |
| spelling | mit-1721.1/1052622022-09-28T18:18:29Z 3D Bioprinting for Tissue and Organ Fabrication Oklu, Rahmi Zhang, Yu Shrike Yue, Kan Aleman, Julio Mollazadeh-Moghaddam, Kamyar Bakht, Syeda Mahwish Yang, Jingzhou Jia, Weitao Dell’Erba, Valeria Assawes, Pribpandao Shin, Su Ryon Dokmeci, Mehmet R. Khademhosseini, Alireza Harvard University--MIT Division of Health Sciences and Technology Zhang, Yu Shrike Yue, Kan Aleman, Julio Mollazadeh-Moghaddam, Kamyar Bakht, Syeda Mahwish Yang, Jingzhou Jia, Weitao Dell’Erba, Valeria Assawes, Pribpandao Shin, Su Ryon Dokmeci, Mehmet R. Khademhosseini, Alireza The field of regenerative medicine has progressed tremendously over the past few decades in its ability to fabricate functional tissue substitutes. Conventional approaches based on scaffolding and microengineering are limited in their capacity of producing tissue constructs with precise biomimetic properties. Three-dimensional (3D) bioprinting technology, on the other hand, promises to bridge the divergence between artificially engineered tissue constructs and native tissues. In a sense, 3D bioprinting offers unprecedented versatility to co-deliver cells and biomaterials with precise control over their compositions, spatial distributions, and architectural accuracy, therefore achieving detailed or even personalized recapitulation of the fine shape, structure, and architecture of target tissues and organs. Here we briefly describe recent progresses of 3D bioprinting technology and associated bioinks suitable for the printing process. We then focus on the applications of this technology in fabrication of biomimetic constructs of several representative tissues and organs, including blood vessel, heart, liver, and cartilage. We finally conclude with future challenges in 3D bioprinting as well as potential solutions for further development. United States. Office of Naval Research. Young Investigator Program National Institutes of Health (U.S.) (Grants EB012597, AR057837, DE021468, HL099073 and R56AI105024) Presidential Early Career Award for Scientists and Engineers 2016-11-08T18:06:58Z 2017-03-01T16:14:47Z 2016-04 2016-01 2016-08-18T15:44:04Z Article http://purl.org/eprint/type/JournalArticle 0090-6964 1573-9686 http://hdl.handle.net/1721.1/105262 Zhang, Yu Shrike et al. “3D Bioprinting for Tissue and Organ Fabrication.” Annals of Biomedical Engineering (2016): n. pag. en http://dx.doi.org/10.1007/s10439-016-1612-8 Annals of Biomedical Engineering Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. Biomedical Engineering Society application/pdf Springer US Springer US |
| spellingShingle | Oklu, Rahmi Zhang, Yu Shrike Yue, Kan Aleman, Julio Mollazadeh-Moghaddam, Kamyar Bakht, Syeda Mahwish Yang, Jingzhou Jia, Weitao Dell’Erba, Valeria Assawes, Pribpandao Shin, Su Ryon Dokmeci, Mehmet R. Khademhosseini, Alireza 3D Bioprinting for Tissue and Organ Fabrication |
| title | 3D Bioprinting for Tissue and Organ Fabrication |
| title_full | 3D Bioprinting for Tissue and Organ Fabrication |
| title_fullStr | 3D Bioprinting for Tissue and Organ Fabrication |
| title_full_unstemmed | 3D Bioprinting for Tissue and Organ Fabrication |
| title_short | 3D Bioprinting for Tissue and Organ Fabrication |
| title_sort | 3d bioprinting for tissue and organ fabrication |
| url | http://hdl.handle.net/1721.1/105262 |
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