Temporal and evolutionary dynamics of two-component signaling pathways
Bacteria sense and respond to numerous environmental signals through two-component signaling pathways. Typically, a given stimulus will activate a sensor histidine kinase to autophosphorylate and then phosphotransfer to a cognate response regulator, which can mount an appropriate response. Although...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/105366 https://orcid.org/0000-0001-6534-104X https://orcid.org/0000-0002-8288-7607 |
| _version_ | 1826215635595558912 |
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| author | Salazar, Michael Edward Laub, Michael T |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Salazar, Michael Edward Laub, Michael T |
| author_sort | Salazar, Michael Edward |
| collection | MIT |
| description | Bacteria sense and respond to numerous environmental signals through two-component signaling pathways. Typically, a given stimulus will activate a sensor histidine kinase to autophosphorylate and then phosphotransfer to a cognate response regulator, which can mount an appropriate
response. Although these signaling pathways often appear to be simple switches, they can also orchestrate surprisingly sophisticated and complex responses. These temporal dynamics arise from several key regulatory features, including the bifunctionality of histidine kinases as well as
positive and negative feedback loops. Two-component signaling pathways are also dynamic on evolutionary time-scales, expanding dramatically in many species through gene duplication and divergence. Here, we review recent work probing the temporal and evolutionary dynamics of two-component signaling systems. |
| first_indexed | 2024-09-23T16:37:03Z |
| format | Article |
| id | mit-1721.1/105366 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:37:03Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1053662022-10-02T08:29:51Z Temporal and evolutionary dynamics of two-component signaling pathways Salazar, Michael Edward Laub, Michael T Massachusetts Institute of Technology. Department of Biology Salazar, Michael Edward Laub, Michael T Bacteria sense and respond to numerous environmental signals through two-component signaling pathways. Typically, a given stimulus will activate a sensor histidine kinase to autophosphorylate and then phosphotransfer to a cognate response regulator, which can mount an appropriate response. Although these signaling pathways often appear to be simple switches, they can also orchestrate surprisingly sophisticated and complex responses. These temporal dynamics arise from several key regulatory features, including the bifunctionality of histidine kinases as well as positive and negative feedback loops. Two-component signaling pathways are also dynamic on evolutionary time-scales, expanding dramatically in many species through gene duplication and divergence. Here, we review recent work probing the temporal and evolutionary dynamics of two-component signaling systems. National Science Foundation (U.S.) (Grant MCB-1408243) National Institutes of Health (U.S.) (Pre-Doctoral Training Grant T32GM007287) 2016-11-18T19:20:52Z 2016-11-18T19:20:52Z 2015-01 Article http://purl.org/eprint/type/JournalArticle 1369-5274 1369-5274 http://hdl.handle.net/1721.1/105366 Salazar, Michael E, and Michael T Laub. “Temporal and Evolutionary Dynamics of Two-Component Signaling Pathways.” Current Opinion in Microbiology 24 (2015): 7–14. https://orcid.org/0000-0001-6534-104X https://orcid.org/0000-0002-8288-7607 en_US http://dx.doi.org/10.1016/j.mib.2014.12.003 Current Opinion in Microbiology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Salazar, Michael Edward Laub, Michael T Temporal and evolutionary dynamics of two-component signaling pathways |
| title | Temporal and evolutionary dynamics of two-component signaling pathways |
| title_full | Temporal and evolutionary dynamics of two-component signaling pathways |
| title_fullStr | Temporal and evolutionary dynamics of two-component signaling pathways |
| title_full_unstemmed | Temporal and evolutionary dynamics of two-component signaling pathways |
| title_short | Temporal and evolutionary dynamics of two-component signaling pathways |
| title_sort | temporal and evolutionary dynamics of two component signaling pathways |
| url | http://hdl.handle.net/1721.1/105366 https://orcid.org/0000-0001-6534-104X https://orcid.org/0000-0002-8288-7607 |
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