A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy

A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy

In normal cells p53 is activated by DNA damage checkpoint kinases to simultaneously control the G1/S and G2/M cell cycle checkpoints through transcriptional induction of p21[superscript cip1] and Gadd45α. In p53 mutant tumors, cell cycle checkpoints are rewired, leading to dependency on the p38/MK2...

Full description

Bibliographic Details
Main Authors: Grant, Robert A., Tsao, Ming-Sound, Cannell, Ian Gordon, Merrick, Karl Andrew, Morandell, Sandra M., Grant, Robert A, Cameron, Eleanor Ruth, Hemann, Michael, Yaffe, Michael B, Braun, Christian Joerg
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/105498
https://orcid.org/0000-0003-4082-0292
https://orcid.org/0000-0002-5229-8748
https://orcid.org/0000-0003-0179-9216
https://orcid.org/0000-0002-9547-3251

Internet

http://hdl.handle.net/1721.1/105498
https://orcid.org/0000-0003-4082-0292
https://orcid.org/0000-0002-5229-8748
https://orcid.org/0000-0003-0179-9216
https://orcid.org/0000-0002-9547-3251

Similar Items