Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis

Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis

Steadily increasing antifungal drug resistance and persistent high rates of fungal-associated mortality highlight the dire need for the development of novel antifungals. Characterization of inhibitors of one enzyme in the GPI anchor pathway, Gwt1, has generated interest in the exploration of targets...

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Bibliographic Details
Main Authors: Mann, Paul A., Koseoglu, Sandra, Si, Qian, Kuzmin, Elena, Flattery, Amy, Harris, Guy, Sher, Xinwei, Murgolo, Nicholas, Wang, Hao, Devito, Kristine, de Pedro, Nuria, Genilloud, Olga, Kahn, Jennifer Nielsen, Jiang, Bo, Costanzo, Michael, Boone, Charlie, Garlisi, Charles G., Roemer, Terry, McLellan, Catherine, Lindquist, Susan
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2016
Online Access:http://hdl.handle.net/1721.1/105537
https://orcid.org/0000-0003-1307-882X

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