Targeted erythropoietin selectively stimulates red blood cell expansion in vivo
The design of cell-targeted protein therapeutics can be informed by natural protein–protein interactions that use cooperative physical contacts to achieve cell type specificity. Here we applied this approach in vivo to the anemia drug erythropoietin (EPO), to direct its activity to EPO receptors (EP...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
National Academy of Sciences (U.S.)
2016
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| Online Access: | http://hdl.handle.net/1721.1/105542 https://orcid.org/0000-0002-5560-8246 |