An Evolutionarily Conserved Prion-like Element Converts Wild Fungi from Metabolic Specialists to Generalists
[GAR[superscript +]] is a protein-based element of inheritance that allows yeast (Saccharomyces cerevisiae) to circumvent a normal hallmark of their biology: extreme metabolic specialization for glucose fermentation. When glucose is present, even in trace quantities, yeast will not use other carbon...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/105721 https://orcid.org/0000-0003-1307-882X |
| _version_ | 1826205273672384512 |
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| author | Jarosz, Daniel F. Lancaster, Alex K. Brown, Jessica Conrad Lindquist, Susan |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Jarosz, Daniel F. Lancaster, Alex K. Brown, Jessica Conrad Lindquist, Susan |
| author_sort | Jarosz, Daniel F. |
| collection | MIT |
| description | [GAR[superscript +]] is a protein-based element of inheritance that allows yeast (Saccharomyces cerevisiae) to circumvent a normal hallmark of their biology: extreme metabolic specialization for glucose fermentation. When glucose is present, even in trace quantities, yeast will not use other carbon
sources. [GAR[superscript +]] allows cells to circumvent this “glucose repression.” [GAR[superscript +]] is induced in yeast by a factor secreted by bacteria inhabiting their environment. We report that the de novo rates of [GAR[superscript +]] appearance correlate with the yeast’s ecological niche. Evolutionarily distant fungi possess similar epigenetic elements that are also induced by bacteria. As expected for a mechanism whose adaptive value originates from the selective pressures of life in biological communities, the ability of bacteria to induce [GAR[superscript +]] and the ability of yeast to respond to bacterial signals have been extinguished repeatedly during the extended monoculture of domestication. Thus, [GAR[superscript +]] is a broadly conserved adaptive strategy that links environmental and social cues to heritable changes in metabolism. |
| first_indexed | 2024-09-23T13:10:06Z |
| format | Article |
| id | mit-1721.1/105721 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:10:06Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1057212022-09-28T12:23:35Z An Evolutionarily Conserved Prion-like Element Converts Wild Fungi from Metabolic Specialists to Generalists Jarosz, Daniel F. Lancaster, Alex K. Brown, Jessica Conrad Lindquist, Susan Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Brown, Jessica Conrad Lindquist, Susan [GAR[superscript +]] is a protein-based element of inheritance that allows yeast (Saccharomyces cerevisiae) to circumvent a normal hallmark of their biology: extreme metabolic specialization for glucose fermentation. When glucose is present, even in trace quantities, yeast will not use other carbon sources. [GAR[superscript +]] allows cells to circumvent this “glucose repression.” [GAR[superscript +]] is induced in yeast by a factor secreted by bacteria inhabiting their environment. We report that the de novo rates of [GAR[superscript +]] appearance correlate with the yeast’s ecological niche. Evolutionarily distant fungi possess similar epigenetic elements that are also induced by bacteria. As expected for a mechanism whose adaptive value originates from the selective pressures of life in biological communities, the ability of bacteria to induce [GAR[superscript +]] and the ability of yeast to respond to bacterial signals have been extinguished repeatedly during the extended monoculture of domestication. Thus, [GAR[superscript +]] is a broadly conserved adaptive strategy that links environmental and social cues to heritable changes in metabolism. G. Harold and Leila Y. Mathers Foundation Howard Hughes Medical Institute 2016-12-05T20:16:45Z 2016-12-05T20:16:45Z 2014-08 Article http://purl.org/eprint/type/JournalArticle 00928674 1097-4172 http://hdl.handle.net/1721.1/105721 Jarosz, Daniel F. et al. “An Evolutionarily Conserved Prion-like Element Converts Wild Fungi from Metabolic Specialists to Generalists.” Cell 158.5 (2014): 1072–1082. https://orcid.org/0000-0003-1307-882X en_US http://dx.doi.org/10.1016/j.cell.2014.07.024 Cell Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Jarosz, Daniel F. Lancaster, Alex K. Brown, Jessica Conrad Lindquist, Susan An Evolutionarily Conserved Prion-like Element Converts Wild Fungi from Metabolic Specialists to Generalists |
| title | An Evolutionarily Conserved Prion-like Element Converts Wild Fungi from Metabolic Specialists to Generalists |
| title_full | An Evolutionarily Conserved Prion-like Element Converts Wild Fungi from Metabolic Specialists to Generalists |
| title_fullStr | An Evolutionarily Conserved Prion-like Element Converts Wild Fungi from Metabolic Specialists to Generalists |
| title_full_unstemmed | An Evolutionarily Conserved Prion-like Element Converts Wild Fungi from Metabolic Specialists to Generalists |
| title_short | An Evolutionarily Conserved Prion-like Element Converts Wild Fungi from Metabolic Specialists to Generalists |
| title_sort | evolutionarily conserved prion like element converts wild fungi from metabolic specialists to generalists |
| url | http://hdl.handle.net/1721.1/105721 https://orcid.org/0000-0003-1307-882X |
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