Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study
Intracoronary optical frequency domain imaging (OFDI), requires the displacement of blood for clear visualization of the artery wall. Radiographic contrast agents are highly effective at displacing blood however, may increase the risk of contrast-induced nephropathy. Flushing media viscosity, flow r...
| Главные авторы: | , , , , , , , , , , , , , |
|---|---|
| Другие авторы: | |
| Формат: | Статья |
| Язык: | English |
| Опубликовано: |
Springer Netherlands
2016
|
| Online-ссылка: | http://hdl.handle.net/1721.1/105790 |
| _version_ | 1826214723797909504 |
|---|---|
| author | Kashiwagi, Manabu Asanani, Nayan Tanaka, Atsushi Tellez, Armando Milewski, Krzysztof Suter, Melissa J. Gallagher, Kevin A. Nadkarni, Seemantini K. Conditt, Gerard B. Kaluza, Greg L. Granada, Juan F. Bouma, Brett E. Tearney, Guillermo J. Bouma, Brett E |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Kashiwagi, Manabu Asanani, Nayan Tanaka, Atsushi Tellez, Armando Milewski, Krzysztof Suter, Melissa J. Gallagher, Kevin A. Nadkarni, Seemantini K. Conditt, Gerard B. Kaluza, Greg L. Granada, Juan F. Bouma, Brett E. Tearney, Guillermo J. Bouma, Brett E |
| author_sort | Kashiwagi, Manabu |
| collection | MIT |
| description | Intracoronary optical frequency domain imaging (OFDI), requires the displacement of blood for clear visualization of the artery wall. Radiographic contrast agents are highly effective at displacing blood however, may increase the risk of contrast-induced nephropathy. Flushing media viscosity, flow rate, and flush duration influence the efficiency of blood displacement necessary for obtaining diagnostic quality OFDI images. The aim of this work was to determine the optimal flushing parameters necessary to reliably perform intracoronary OFDI while reducing the volume of administered radiographic contrast, and assess the influence of flushing media choice on vessel wall measurements. 144 OFDI pullbacks were acquired together with synchronized EKG and intracoronary pressure wire recordings in three swine. OFDI images were graded on diagnostic quality and quantitative comparisons of flushing efficiency and intracoronary cross-sectional area with and without precise refractive index calibration were performed. Flushing media with higher viscosities resulted in rapid and efficient blood displacement. Media with lower viscosities resulted in increased blood-media transition zones, reducing the pullback length of diagnostic quality images obtained. Flushing efficiency was found to increase with increases in flow rate and duration. Calculations of lumen area using different flushing media were significantly different, varying up to 23 % (p < 0.0001). This error was eliminated with careful refractive index calibration. Flushing media viscosity, flow rate, and flush duration influence the efficiency of blood displacement necessary for obtaining diagnostic quality OFDI images. For patients with sensitivity to contrast, to reduce the risk of contrast induced nephrotoxicity we recommend that intracoronary OFDI be conducted with flushing solutions containing little or no radiographic contrast. In addition, our findings show that careful refractive index compensation should be performed, taking into account the specific contrast agent used, in order to obtain accurate intravascular OFDI measurements. |
| first_indexed | 2024-09-23T16:10:08Z |
| format | Article |
| id | mit-1721.1/105790 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:10:08Z |
| publishDate | 2016 |
| publisher | Springer Netherlands |
| record_format | dspace |
| spelling | mit-1721.1/1057902024-03-20T19:31:35Z Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study Kashiwagi, Manabu Asanani, Nayan Tanaka, Atsushi Tellez, Armando Milewski, Krzysztof Suter, Melissa J. Gallagher, Kevin A. Nadkarni, Seemantini K. Conditt, Gerard B. Kaluza, Greg L. Granada, Juan F. Bouma, Brett E. Tearney, Guillermo J. Bouma, Brett E Massachusetts Institute of Technology. Institute for Medical Engineering & Science Harvard University--MIT Division of Health Sciences and Technology Bouma, Brett E Tearney, Guillermo J. Intracoronary optical frequency domain imaging (OFDI), requires the displacement of blood for clear visualization of the artery wall. Radiographic contrast agents are highly effective at displacing blood however, may increase the risk of contrast-induced nephropathy. Flushing media viscosity, flow rate, and flush duration influence the efficiency of blood displacement necessary for obtaining diagnostic quality OFDI images. The aim of this work was to determine the optimal flushing parameters necessary to reliably perform intracoronary OFDI while reducing the volume of administered radiographic contrast, and assess the influence of flushing media choice on vessel wall measurements. 144 OFDI pullbacks were acquired together with synchronized EKG and intracoronary pressure wire recordings in three swine. OFDI images were graded on diagnostic quality and quantitative comparisons of flushing efficiency and intracoronary cross-sectional area with and without precise refractive index calibration were performed. Flushing media with higher viscosities resulted in rapid and efficient blood displacement. Media with lower viscosities resulted in increased blood-media transition zones, reducing the pullback length of diagnostic quality images obtained. Flushing efficiency was found to increase with increases in flow rate and duration. Calculations of lumen area using different flushing media were significantly different, varying up to 23 % (p < 0.0001). This error was eliminated with careful refractive index calibration. Flushing media viscosity, flow rate, and flush duration influence the efficiency of blood displacement necessary for obtaining diagnostic quality OFDI images. For patients with sensitivity to contrast, to reduce the risk of contrast induced nephrotoxicity we recommend that intracoronary OFDI be conducted with flushing solutions containing little or no radiographic contrast. In addition, our findings show that careful refractive index compensation should be performed, taking into account the specific contrast agent used, in order to obtain accurate intravascular OFDI measurements. Merck & Co., Inc. National Institutes of Health (U.S.) (Grant Numbers R00CA134920, R01HL076398, R01HL093717) 2016-12-09T20:46:34Z 2016-12-09T20:46:34Z 2015-04 2014-09 2016-08-18T15:20:19Z Article http://purl.org/eprint/type/JournalArticle 1569-5794 1573-0743 http://hdl.handle.net/1721.1/105790 Suter, Melissa J., Manabu Kashiwagi, Kevin A. Gallagher, Seemantini K. Nadkarni, Nayan Asanani, Atsushi Tanaka, Gerard B. Conditt, et al. “Optimizing Flushing Parameters in Intracoronary Optical Coherence Tomography: An in Vivo Swine Study.” Int J Cardiovasc Imaging 31, no. 6 (April 29, 2015): 1097–1106. en http://dx.doi.org/10.1007/s10554-015-0668-0 The International Journal of Cardiovascular Imaging Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. Springer Science+Business Media Dordrecht application/pdf Springer Netherlands Springer Netherlands |
| spellingShingle | Kashiwagi, Manabu Asanani, Nayan Tanaka, Atsushi Tellez, Armando Milewski, Krzysztof Suter, Melissa J. Gallagher, Kevin A. Nadkarni, Seemantini K. Conditt, Gerard B. Kaluza, Greg L. Granada, Juan F. Bouma, Brett E. Tearney, Guillermo J. Bouma, Brett E Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study |
| title | Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study |
| title_full | Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study |
| title_fullStr | Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study |
| title_full_unstemmed | Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study |
| title_short | Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study |
| title_sort | optimizing flushing parameters in intracoronary optical coherence tomography an in vivo swine study |
| url | http://hdl.handle.net/1721.1/105790 |
| work_keys_str_mv | AT kashiwagimanabu optimizingflushingparametersinintracoronaryopticalcoherencetomographyaninvivoswinestudy AT asananinayan optimizingflushingparametersinintracoronaryopticalcoherencetomographyaninvivoswinestudy AT tanakaatsushi optimizingflushingparametersinintracoronaryopticalcoherencetomographyaninvivoswinestudy AT tellezarmando optimizingflushingparametersinintracoronaryopticalcoherencetomographyaninvivoswinestudy AT milewskikrzysztof optimizingflushingparametersinintracoronaryopticalcoherencetomographyaninvivoswinestudy AT sutermelissaj optimizingflushingparametersinintracoronaryopticalcoherencetomographyaninvivoswinestudy AT gallagherkevina optimizingflushingparametersinintracoronaryopticalcoherencetomographyaninvivoswinestudy AT nadkarniseemantinik optimizingflushingparametersinintracoronaryopticalcoherencetomographyaninvivoswinestudy AT condittgerardb optimizingflushingparametersinintracoronaryopticalcoherencetomographyaninvivoswinestudy AT kaluzagregl optimizingflushingparametersinintracoronaryopticalcoherencetomographyaninvivoswinestudy AT granadajuanf optimizingflushingparametersinintracoronaryopticalcoherencetomographyaninvivoswinestudy AT boumabrette optimizingflushingparametersinintracoronaryopticalcoherencetomographyaninvivoswinestudy AT tearneyguillermoj optimizingflushingparametersinintracoronaryopticalcoherencetomographyaninvivoswinestudy AT boumabrette optimizingflushingparametersinintracoronaryopticalcoherencetomographyaninvivoswinestudy |