Phosphorylation of ETS1 by Src Family Kinases Prevents Its Recognition by the COP1 Tumor Suppressor

Phosphorylation of ETS1 by Src Family Kinases Prevents Its Recognition by the COP1 Tumor Suppressor

Oncoproteins and tumor suppressors antagonistically converge on critical nodes governing neoplastic growth, invasion, and metastasis. We discovered that phosphorylation of the ETS1 and ETS2 transcriptional oncoproteins at specific serine or threonine residues creates binding sites for the COP1 tumor...

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Bibliographic Details
Main Authors: Lu, Gang, Zhang, Qing, Huang, Ying, Song, Jiaxi, Lim, Elgene, Liu, Wenbin, Bronson, Roderick T., Bowden, Michaela, Brock, Jane, Krop, Ian E., Dillon, Deborah A., Gygi, Steven P., Mills, Gordon B., Richardson, Andrea L., Signoretti, Sabina, Kaelin, William G., Tomaino, Ross, Yaffe, Michael B, Ehrenberger, Tobias
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/105867
https://orcid.org/0000-0002-9547-3251
https://orcid.org/0000-0001-7963-402X

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