Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle
Purpose: Cross-talk and feedback between the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR cell signaling pathways is critical for tumor initiation, maintenance, and adaptive resistance to targeted therapy in a variety of solid tumors. Combined blockade of these pathways—horizontal blockade—is a promising thera...
Main Authors: | , , , , , , , , , |
---|---|
Other Authors: | |
Format: | Article |
Language: | en_US |
Published: |
American Association for Cancer Research
2016
|
Online Access: | http://hdl.handle.net/1721.1/105871 https://orcid.org/0000-0002-4954-8443 https://orcid.org/0000-0002-4223-971X https://orcid.org/0000-0001-8230-4945 https://orcid.org/0000-0002-8848-7559 https://orcid.org/0000-0003-3988-0837 https://orcid.org/0000-0001-6865-4084 https://orcid.org/0000-0002-9547-3251 |
Internet
http://hdl.handle.net/1721.1/105871https://orcid.org/0000-0002-4954-8443
https://orcid.org/0000-0002-4223-971X
https://orcid.org/0000-0001-8230-4945
https://orcid.org/0000-0002-8848-7559
https://orcid.org/0000-0003-3988-0837
https://orcid.org/0000-0001-6865-4084
https://orcid.org/0000-0002-9547-3251