A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

The “cancerized field” concept posits that cancer-prone cells in a given tissue share an oncogenic mutation, but only discreet clones within the field initiate tumors. Most benign nevi carry oncogenic BRAF[superscript V600E] mutations but rarely become melanoma. The zebrafish crestin gene is express...

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Bibliographic Details
Main Authors: Kaufman, C. K., Mosimann, C., Yang, S., Thomas, A. J., Ablain, J., Tan, J. L., Fogley, R. D., van Rooijen, E., Hagedorn, E. J., Ciarlo, C., White, R. M., Matos, D. A., Puller, A.-C., Santoriello, C., Liao, E. C., Zon, L. I., Fan, Zi Peng, Young, Richard A.
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Language:en_US
Published: American Association for the Advancement of Science (AAAS) 2016
Online Access:http://hdl.handle.net/1721.1/105872
https://orcid.org/0000-0001-8855-8647

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