Stochastic but Highly Coordinated Protein Unfolding and Translocation by the ClpXP Proteolytic Machine

Stochastic but Highly Coordinated Protein Unfolding and Translocation by the ClpXP Proteolytic Machine

ClpXP and other AAA+ proteases recognize, mechanically unfold, and translocate target proteins into a chamber for proteolysis. It is not known whether these remarkable molecular machines operate by a stochastic or sequential mechanism or how power strokes relate to the ATP-hydrolysis cycle. Single-m...

Full description

Bibliographic Details
Main Authors: Cordova, Juan Carlos, Aubin-Tam, Marie-Eve, Lang, Matthew J., Olivares, Adrian O., Shin, Yongdae, Calmat, Stephane Geraldine Michele, Schmitz, Karl Robert, Baker, Tania, Sauer, Robert T., Stinson, Benjamin Michael
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/106303
https://orcid.org/0000-0002-1081-285X
https://orcid.org/0000-0002-9309-8662
https://orcid.org/0000-0002-1719-5399

Internet

http://hdl.handle.net/1721.1/106303
https://orcid.org/0000-0002-1081-285X
https://orcid.org/0000-0002-9309-8662
https://orcid.org/0000-0002-1719-5399

Similar Items