Stochastic but Highly Coordinated Protein Unfolding and Translocation by the ClpXP Proteolytic Machine
ClpXP and other AAA+ proteases recognize, mechanically unfold, and translocate target proteins into a chamber for proteolysis. It is not known whether these remarkable molecular machines operate by a stochastic or sequential mechanism or how power strokes relate to the ATP-hydrolysis cycle. Single-m...
| Main Authors: | , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2017
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| Online Access: | http://hdl.handle.net/1721.1/106303 https://orcid.org/0000-0002-1081-285X https://orcid.org/0000-0002-9309-8662 https://orcid.org/0000-0002-1719-5399 |