SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7

SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7

Scavenger receptor class B, member 2 (SCARB2) is essential for endosome biogenesis and reorganization and serves as a receptor for both β-glucocerebrosidase and enterovirus 71. However, little is known about its function in innate immune cells. In this study, we show that, among human peripheral blo...

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Bibliographic Details
Main Authors: Guo, H., Zhang, J., Zhang, X., Wang, Y., Yu, H., Yin, X., Li, J., Du, P., Plumas, J., Chaperot, L., Su, L., Liu, Y., Zhang, L., Chen, Jianzhu
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association of Immunologists 2017
Online Access:http://hdl.handle.net/1721.1/106316
https://orcid.org/0000-0002-5687-6154

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