D-Cyclins Repress Apoptosis in Hematopoietic Cells by Controlling Death Receptor Fas and Its Ligand FasL

D-Cyclins Repress Apoptosis in Hematopoietic Cells by Controlling Death Receptor Fas and Its Ligand FasL

D-type cyclins (D1, D2, and D3) are components of the mammalian core cell-cycle machinery and function to drive cell proliferation. Here, we report that D-cyclins perform a rate-limiting antiapoptotic function in vivo. We found that acute shutdown of all three D-cyclins in bone marrow of adult mice...

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Bibliographic Details
Main Authors: Choi, Yoon Jong, Saez, Borja, Anders, Lars, Hydbring, Per, Stefano, Joanna, Bacon, Nickolas A., Cook, Colleen, Kalaszczynska, Ilona, Signoretti, Sabina, Scadden, David T., Sicinski, Piotr, Young, Richard A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/106321
https://orcid.org/0000-0001-8855-8647

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