Low-level laser therapy (LLLT) combined with swimming training improved the lipid profile in rats fed with high-fat diet
Obesity and associated dyslipidemia is the fastest growing health problem throughout the world. The combination of exercise and low-level laser therapy (LLLT) could be a new approach to the treatment of obesity and associated disease. In this work, the effects of LLLT associated with exercises on th...
| Main Authors: | , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer London
2017
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| Online Access: | http://hdl.handle.net/1721.1/106486 |
| _version_ | 1826201352476295168 |
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| author | Sene-Fiorese, Marcela Aquino, Antonio E. Paolillo, Fernanda R. Duarte, Fernanda O. Oishi, Jorge C. Pena, Airton A. Duarte, Ana C. G. O. Bagnato, Vanderlei S. Parizotto, Nivaldo A. Hamblin, Michael R. |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Sene-Fiorese, Marcela Aquino, Antonio E. Paolillo, Fernanda R. Duarte, Fernanda O. Oishi, Jorge C. Pena, Airton A. Duarte, Ana C. G. O. Bagnato, Vanderlei S. Parizotto, Nivaldo A. Hamblin, Michael R. |
| author_sort | Sene-Fiorese, Marcela |
| collection | MIT |
| description | Obesity and associated dyslipidemia is the fastest growing health problem throughout the world. The combination of exercise and low-level laser therapy (LLLT) could be a new approach to the treatment of obesity and associated disease. In this work, the effects of LLLT associated with exercises on the lipid metabolism in regular and high-fat diet rats were verified. We used 64 rats divided in eight groups with eight rats each, designed: SC, sedentary chow diet; SCL, sedentary chow diet laser, TC, trained chow diet; TCL, trained chow diet laser; SH, sedentary high-fat diet; SHL, sedentary high-fat diet laser; TH, trained high-fat diet; and THL, trained high-fat diet laser. The exercise used was swimming during 8 weeks/90 min daily and LLLT (GA-Al-As, 830 nm) dose of 4.7 J/point and total energy 9.4 J per animal, applied to both gastrocnemius muscles after exercise. We analyzed biochemical parameters, percentage of fat, hepatic and muscular glycogen and relative mass of tissue, and weight percentage gain. The statistical test used was ANOVA, with post hoc Tukey–Kramer for multiple analysis between groups, and the significant level was p < 0.001, p < 0.01, and p < 0.05. LLLT decreased the total cholesterol (p < 0.05), triglycerides (p < 0.01), low-density lipoprotein cholesterol (p < 0.05), and relative mass of fat tissue (p < 0.05), suggesting increased metabolic activity and altered lipid pathways. The combination of exercise and LLLT increased the benefits of exercise alone. However, LLLT without exercise tended to increase body weight and fat content. LLLT may be a valuable addition to a regimen of diet and exercise for weight reduction and dyslipidemic control. |
| first_indexed | 2024-09-23T11:50:16Z |
| format | Article |
| id | mit-1721.1/106486 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:50:16Z |
| publishDate | 2017 |
| publisher | Springer London |
| record_format | dspace |
| spelling | mit-1721.1/1064862022-09-27T22:17:15Z Low-level laser therapy (LLLT) combined with swimming training improved the lipid profile in rats fed with high-fat diet Sene-Fiorese, Marcela Aquino, Antonio E. Paolillo, Fernanda R. Duarte, Fernanda O. Oishi, Jorge C. Pena, Airton A. Duarte, Ana C. G. O. Bagnato, Vanderlei S. Parizotto, Nivaldo A. Hamblin, Michael R. Massachusetts Institute of Technology. Institute for Medical Engineering & Science Harvard University--MIT Division of Health Sciences and Technology Hamblin, Michael R Obesity and associated dyslipidemia is the fastest growing health problem throughout the world. The combination of exercise and low-level laser therapy (LLLT) could be a new approach to the treatment of obesity and associated disease. In this work, the effects of LLLT associated with exercises on the lipid metabolism in regular and high-fat diet rats were verified. We used 64 rats divided in eight groups with eight rats each, designed: SC, sedentary chow diet; SCL, sedentary chow diet laser, TC, trained chow diet; TCL, trained chow diet laser; SH, sedentary high-fat diet; SHL, sedentary high-fat diet laser; TH, trained high-fat diet; and THL, trained high-fat diet laser. The exercise used was swimming during 8 weeks/90 min daily and LLLT (GA-Al-As, 830 nm) dose of 4.7 J/point and total energy 9.4 J per animal, applied to both gastrocnemius muscles after exercise. We analyzed biochemical parameters, percentage of fat, hepatic and muscular glycogen and relative mass of tissue, and weight percentage gain. The statistical test used was ANOVA, with post hoc Tukey–Kramer for multiple analysis between groups, and the significant level was p < 0.001, p < 0.01, and p < 0.05. LLLT decreased the total cholesterol (p < 0.05), triglycerides (p < 0.01), low-density lipoprotein cholesterol (p < 0.05), and relative mass of fat tissue (p < 0.05), suggesting increased metabolic activity and altered lipid pathways. The combination of exercise and LLLT increased the benefits of exercise alone. However, LLLT without exercise tended to increase body weight and fat content. LLLT may be a valuable addition to a regimen of diet and exercise for weight reduction and dyslipidemic control. 2017-01-13T20:56:03Z 2017-01-13T20:56:03Z 2012-11 2012-06 2016-08-18T15:21:07Z Article http://purl.org/eprint/type/JournalArticle 0268-8921 1435-604X http://hdl.handle.net/1721.1/106486 Aquino, Antonio E., Marcela Sene-Fiorese, Fernanda R. Paolillo, Fernanda O. Duarte, Jorge C. Oishi, Airton A. Pena, Ana C. G. O. Duarte, Michael R. Hamblin, Vanderlei S. Bagnato, and Nivaldo A. Parizotto. “Low-Level Laser Therapy (LLLT) Combined with Swimming Training Improved the Lipid Profile in Rats Fed with High-Fat Diet.” Lasers Med Sci 28, no. 5 (November 14, 2012): 1271–1280. en http://dx.doi.org/10.1007/s10103-012-1223-z Lasers in Medical Science Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. Springer-Verlag London application/pdf Springer London Springer London |
| spellingShingle | Sene-Fiorese, Marcela Aquino, Antonio E. Paolillo, Fernanda R. Duarte, Fernanda O. Oishi, Jorge C. Pena, Airton A. Duarte, Ana C. G. O. Bagnato, Vanderlei S. Parizotto, Nivaldo A. Hamblin, Michael R. Low-level laser therapy (LLLT) combined with swimming training improved the lipid profile in rats fed with high-fat diet |
| title | Low-level laser therapy (LLLT) combined with swimming training improved the lipid profile in rats fed with high-fat diet |
| title_full | Low-level laser therapy (LLLT) combined with swimming training improved the lipid profile in rats fed with high-fat diet |
| title_fullStr | Low-level laser therapy (LLLT) combined with swimming training improved the lipid profile in rats fed with high-fat diet |
| title_full_unstemmed | Low-level laser therapy (LLLT) combined with swimming training improved the lipid profile in rats fed with high-fat diet |
| title_short | Low-level laser therapy (LLLT) combined with swimming training improved the lipid profile in rats fed with high-fat diet |
| title_sort | low level laser therapy lllt combined with swimming training improved the lipid profile in rats fed with high fat diet |
| url | http://hdl.handle.net/1721.1/106486 |
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