Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
Follicular lymphoma is an incurable B cell malignancy characterized by the t(14;18) translocation and mutations affecting the epigenome. Although frequent gene mutations in key signaling pathways, including JAK-STAT, NOTCH and NF-κB, have also been defined, the spectrum of these mutations typically...
Main Authors: | Sabatini, David, Wolfson, Rachel Laura, Efeyan, Alejo |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
Nature Publishing Group
2017
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Online Access: | http://hdl.handle.net/1721.1/106517 https://orcid.org/0000-0002-1446-7256 https://orcid.org/0000-0002-9535-7664 |
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