Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets
Brain metastases are associated with a dismal prognosis. Whether brain metastases harbor distinct genetic alterations beyond those observed in primary tumors is unknown. We performed wholeexome sequencing of 86 matched brain metastases, primary tumors and normal tissue. In all clonally related canc...
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| Format: | Article |
| Language: | en_US |
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American Association for Cancer Research
2017
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| Online Access: | http://hdl.handle.net/1721.1/106521 |