Layer-specific interhemispheric functional connectivity in the somatosensory cortex of rats: resting state electrophysiology and fMRI studies
The spontaneous cerebral hemodynamic fluctuations observed during the resting state have been frequently visualized using functional magnetic resonance imaging (rsfMRI). However, the neuronal populations and neuroelectric characteristics underlying the functional connectivity of cerebrohemodynamic a...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer Berlin Heidelberg
2017
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| Online Access: | http://hdl.handle.net/1721.1/106537 |
| _version_ | 1811088230673547264 |
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| author | Baek, Kwangyeol Jeong, Jaeseung Radhakrishnan, Harsha Shim, Woo Hyun Biswal, Bharat B. Kim, Young R. Rosen, Bruce R Boas, David A Franceschini, Maria Angela |
| author2 | Institute for Medical Engineering and Science |
| author_facet | Institute for Medical Engineering and Science Baek, Kwangyeol Jeong, Jaeseung Radhakrishnan, Harsha Shim, Woo Hyun Biswal, Bharat B. Kim, Young R. Rosen, Bruce R Boas, David A Franceschini, Maria Angela |
| author_sort | Baek, Kwangyeol |
| collection | MIT |
| description | The spontaneous cerebral hemodynamic fluctuations observed during the resting state have been frequently visualized using functional magnetic resonance imaging (rsfMRI). However, the neuronal populations and neuroelectric characteristics underlying the functional connectivity of cerebrohemodynamic activities are poorly understood. We investigated the characteristics of bi-hemispheric functional connectivity via electrophysiology and rsfMRI in the primary sensory cortex of rats anesthetized by α-chloralose. Unlike the evoked responses, the spontaneous electrophysiological activity was concentrated in the infragranular layers and could be classified into subtypes with distinctive current sources and sinks. Both neuroelectric and rsfMRI signals were interhemispherically correlated in a layer-specific manner, suggesting that there are independent neural inputs to infragranular and granular/supragranular layers. The majority of spontaneous electrophysiological activities were bilaterally paired with delays of up to ~50 ms between each pair. The variable interhemispheric delay implies the involvement of indirect, multi-neural pathways. Our findings demonstrated the diverse activity patterns of layer-specific electrophysiological substrates and suggest the recruitment of multiple, non-specific brain regions in construction of interhemispheric functional connectivity. |
| first_indexed | 2024-09-23T13:58:46Z |
| format | Article |
| id | mit-1721.1/106537 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T13:58:46Z |
| publishDate | 2017 |
| publisher | Springer Berlin Heidelberg |
| record_format | dspace |
| spelling | mit-1721.1/1065372022-09-28T17:30:35Z Layer-specific interhemispheric functional connectivity in the somatosensory cortex of rats: resting state electrophysiology and fMRI studies Baek, Kwangyeol Jeong, Jaeseung Radhakrishnan, Harsha Shim, Woo Hyun Biswal, Bharat B. Kim, Young R. Rosen, Bruce R Boas, David A Franceschini, Maria Angela Institute for Medical Engineering and Science Harvard University--MIT Division of Health Sciences and Technology Rosen, Bruce R Boas, David A Franceschini, Maria Angela The spontaneous cerebral hemodynamic fluctuations observed during the resting state have been frequently visualized using functional magnetic resonance imaging (rsfMRI). However, the neuronal populations and neuroelectric characteristics underlying the functional connectivity of cerebrohemodynamic activities are poorly understood. We investigated the characteristics of bi-hemispheric functional connectivity via electrophysiology and rsfMRI in the primary sensory cortex of rats anesthetized by α-chloralose. Unlike the evoked responses, the spontaneous electrophysiological activity was concentrated in the infragranular layers and could be classified into subtypes with distinctive current sources and sinks. Both neuroelectric and rsfMRI signals were interhemispherically correlated in a layer-specific manner, suggesting that there are independent neural inputs to infragranular and granular/supragranular layers. The majority of spontaneous electrophysiological activities were bilaterally paired with delays of up to ~50 ms between each pair. The variable interhemispheric delay implies the involvement of indirect, multi-neural pathways. Our findings demonstrated the diverse activity patterns of layer-specific electrophysiological substrates and suggest the recruitment of multiple, non-specific brain regions in construction of interhemispheric functional connectivity. 2017-01-19T19:51:11Z 2017-01-19T19:51:11Z 2015-06 2014-06 2016-08-18T15:27:15Z Article http://purl.org/eprint/type/JournalArticle 1863-2653 1863-2661 http://hdl.handle.net/1721.1/106537 Baek, Kwangyeol et al. “Layer-Specific Interhemispheric Functional Connectivity in the Somatosensory Cortex of Rats: Resting State Electrophysiology and fMRI Studies.” Brain Structure and Function 221.5 (2016): 2801–2815. en http://dx.doi.org/10.1007/s00429-015-1073-0 Brain Structure and Function Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. Springer-Verlag Berlin Heidelberg application/pdf Springer Berlin Heidelberg Springer Berlin Heidelberg |
| spellingShingle | Baek, Kwangyeol Jeong, Jaeseung Radhakrishnan, Harsha Shim, Woo Hyun Biswal, Bharat B. Kim, Young R. Rosen, Bruce R Boas, David A Franceschini, Maria Angela Layer-specific interhemispheric functional connectivity in the somatosensory cortex of rats: resting state electrophysiology and fMRI studies |
| title | Layer-specific interhemispheric functional connectivity in the somatosensory cortex of rats: resting state electrophysiology and fMRI studies |
| title_full | Layer-specific interhemispheric functional connectivity in the somatosensory cortex of rats: resting state electrophysiology and fMRI studies |
| title_fullStr | Layer-specific interhemispheric functional connectivity in the somatosensory cortex of rats: resting state electrophysiology and fMRI studies |
| title_full_unstemmed | Layer-specific interhemispheric functional connectivity in the somatosensory cortex of rats: resting state electrophysiology and fMRI studies |
| title_short | Layer-specific interhemispheric functional connectivity in the somatosensory cortex of rats: resting state electrophysiology and fMRI studies |
| title_sort | layer specific interhemispheric functional connectivity in the somatosensory cortex of rats resting state electrophysiology and fmri studies |
| url | http://hdl.handle.net/1721.1/106537 |
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