Activation of proto-oncogenes by disruption of chromosome neighborhoods

Activation of proto-oncogenes by disruption of chromosome neighborhoods

Oncogenes are activated through well-known chromosomal alterations such as gene fusion, translocation, and focal amplification. In light of recent evidence that the control of key genes depends on chromosome structures called insulated neighborhoods, we investigated whether proto-oncogenes occur wit...

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Bibliographic Details
Main Authors: Hnisz, D., Day, D. S., Valton, A.-L., Bak, R. O., Goldmann, J., Lajoie, B. R., Sigova, A. A., Lee, T. I., Porteus, M. H., Dekker, J., Weintraub, Abraham Selby, Li, Charles Han, Reddy, Jessica, Borges-Rivera, Diego Ramon, Jaenisch, Rudolf, Fan, Zi Peng, Young, Richard A.
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Language:en_US
Published: American Association for the Advancement of Science (AAAS) 2017
Online Access:http://hdl.handle.net/1721.1/106605
https://orcid.org/0000-0003-0998-9882
https://orcid.org/0000-0001-8091-6112
https://orcid.org/0000-0002-2171-9394
https://orcid.org/0000-0002-1650-2289
https://orcid.org/0000-0001-8855-8647

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