SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

Cancer cells adapt their metabolic processes to support rapid proliferation, but less is known about how cancer cells alter metabolism to promote cell survival in a poorly vascularized tumour microenvironment1, 2, 3. Here we identify a key role for serine and glycine metabolism in the survival of br...

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Bibliographic Details
Main Authors: Kami, Kenjiro, Shelton, Laura M., Ramkissoon, Shakti H., Ligon, Keith L., Snuderl, Matija, Kim, Dohoon, Fiske, Brian Prescott, Birsoy, Kivanc, Freinkman, Elizaveta, Possemato, Richard, Chudnovsky, Yakov, Chen, Walter W., Cantor, Jason R., Gui, Dan Yi, Kwon, ManJae, Kang, Seong Woo, Vander Heiden, Matthew G., Sabatini, David, Pacold, Michael Edward
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/106619
https://orcid.org/0000-0002-2401-0030
https://orcid.org/0000-0003-3688-2378
https://orcid.org/0000-0002-7043-5013
https://orcid.org/0000-0003-0130-3428
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/106619
https://orcid.org/0000-0002-2401-0030
https://orcid.org/0000-0003-3688-2378
https://orcid.org/0000-0002-7043-5013
https://orcid.org/0000-0003-0130-3428
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0002-1446-7256

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