Ventral CA1 neurons store social memory
The medial temporal lobe, including the hippocampus, has been implicated in social memory. However, it remains unknown which parts of these brain regions and their circuits hold social memory. Here, we show that ventral hippocampal CA1 (vCA1) neurons of a mouse and their projections to nucleus accum...
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| Format: | Article |
| Language: | en_US |
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American Association for the Advancement of Science (AAAS)
2017
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| Online Access: | http://hdl.handle.net/1721.1/106627 https://orcid.org/0000-0003-1566-0063 https://orcid.org/0000-0002-5218-1216 https://orcid.org/0000-0003-2839-8228 |
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| author | Itohara, Shigeyoshi Okuyama, Teruhiro Kitamura, Takashi Roy, Dheeraj Tonegawa, Susumu |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Itohara, Shigeyoshi Okuyama, Teruhiro Kitamura, Takashi Roy, Dheeraj Tonegawa, Susumu |
| author_sort | Itohara, Shigeyoshi |
| collection | MIT |
| description | The medial temporal lobe, including the hippocampus, has been implicated in social memory. However, it remains unknown which parts of these brain regions and their circuits hold social memory. Here, we show that ventral hippocampal CA1 (vCA1) neurons of a mouse and their projections to nucleus accumbens (NAc) shell play a necessary and sufficient role in social memory. Both the proportion of activated vCA1 cells and the strength and stability of the responding cells are greater in response to a familiar mouse than to a previously unencountered mouse. Optogenetic reactivation of vCA1 neurons that respond to the familiar mouse enabled memory retrieval and the association of these neurons with unconditioned stimuli. Thus, vCA1 neurons and their NAc shell projections are a component of the storage site of social memory. |
| first_indexed | 2024-09-23T10:44:37Z |
| format | Article |
| id | mit-1721.1/106627 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:44:37Z |
| publishDate | 2017 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1066272022-09-27T14:41:48Z Ventral CA1 neurons store social memory Itohara, Shigeyoshi Okuyama, Teruhiro Kitamura, Takashi Roy, Dheeraj Tonegawa, Susumu Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory RIKEN-MIT Center for Neural Circuit Genetics Tonegawa, Susumu Okuyama, Teruhiro Kitamura, Takashi Roy, Dheeraj Tonegawa, Susumu The medial temporal lobe, including the hippocampus, has been implicated in social memory. However, it remains unknown which parts of these brain regions and their circuits hold social memory. Here, we show that ventral hippocampal CA1 (vCA1) neurons of a mouse and their projections to nucleus accumbens (NAc) shell play a necessary and sufficient role in social memory. Both the proportion of activated vCA1 cells and the strength and stability of the responding cells are greater in response to a familiar mouse than to a previously unencountered mouse. Optogenetic reactivation of vCA1 neurons that respond to the familiar mouse enabled memory retrieval and the association of these neurons with unconditioned stimuli. Thus, vCA1 neurons and their NAc shell projections are a component of the storage site of social memory. Howard Hughes Medical Institute RIKEN Brain Science Institute JPB Foundation Japan Society for the Promotion of Science (Grant-In-Aid) 2017-01-25T21:28:55Z 2017-01-25T21:28:55Z 2016-09 Article http://purl.org/eprint/type/JournalArticle 0036-8075 1095-9203 http://hdl.handle.net/1721.1/106627 Okuyama, T., T. Kitamura, D. S. Roy, S. Itohara, and S. Tonegawa. “Ventral CA1 Neurons Store Social Memory.” Science 353, no. 6307 (September 29, 2016): 1536-1541. https://orcid.org/0000-0003-1566-0063 https://orcid.org/0000-0002-5218-1216 https://orcid.org/0000-0003-2839-8228 en_US http://dx.doi.org/10.1126/science.aaf7003 Science Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Association for the Advancement of Science (AAAS) Prof. Tonegawa via Courtney Crummett |
| spellingShingle | Itohara, Shigeyoshi Okuyama, Teruhiro Kitamura, Takashi Roy, Dheeraj Tonegawa, Susumu Ventral CA1 neurons store social memory |
| title | Ventral CA1 neurons store social memory |
| title_full | Ventral CA1 neurons store social memory |
| title_fullStr | Ventral CA1 neurons store social memory |
| title_full_unstemmed | Ventral CA1 neurons store social memory |
| title_short | Ventral CA1 neurons store social memory |
| title_sort | ventral ca1 neurons store social memory |
| url | http://hdl.handle.net/1721.1/106627 https://orcid.org/0000-0003-1566-0063 https://orcid.org/0000-0002-5218-1216 https://orcid.org/0000-0003-2839-8228 |
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