Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD)
Deep Brain Stimulation (DBS) is a neurosurgical procedure that can reduce symptoms in medically intractable obsessive-compulsive disorder (OCD). Conceptually, DBS of the ventral capsule/ventral striatum (VC/VS) region targets reciprocal excitatory connections between the orbitofrontal cortex (OFC) a...
| Main Authors: | , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Springer US
2017
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| Online Access: | http://hdl.handle.net/1721.1/106645 https://orcid.org/0000-0001-8510-341X |
| _version_ | 1811085687593631744 |
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| author | Makris, Nikolaos Rathi, Yogesh Mouradian, Palig Bonmassar, Giorgio Papadimitriou, George Kubicki, Marek Fan, Qiuyun Nummenmaa, Aapo Ing, Wingkwai I. Yeterian, Edward H. Eskandar, Emad N. Wald, Lawrence L. Dougherty, Darin D. Widge, Alik |
| author2 | Picower Institute for Learning and Memory |
| author_facet | Picower Institute for Learning and Memory Makris, Nikolaos Rathi, Yogesh Mouradian, Palig Bonmassar, Giorgio Papadimitriou, George Kubicki, Marek Fan, Qiuyun Nummenmaa, Aapo Ing, Wingkwai I. Yeterian, Edward H. Eskandar, Emad N. Wald, Lawrence L. Dougherty, Darin D. Widge, Alik |
| author_sort | Makris, Nikolaos |
| collection | MIT |
| description | Deep Brain Stimulation (DBS) is a neurosurgical procedure that can reduce symptoms in medically intractable obsessive-compulsive disorder (OCD). Conceptually, DBS of the ventral capsule/ventral striatum (VC/VS) region targets reciprocal excitatory connections between the orbitofrontal cortex (OFC) and thalamus, decreasing abnormal reverberant activity within the OFC-caudate-pallidal-thalamic circuit. In this study, we investigated these connections using diffusion magnetic resonance imaging (dMRI) on human connectome datasets of twenty-nine healthy young-adult volunteers with two-tensor unscented Kalman filter based tractography. We studied the morphology of the lateral and medial orbitofrontothalamic connections and estimated their topographic variability within the VC/VS region. Our results showed that the morphology of the individual orbitofrontothalamic fibers of passage in the VC/VS region is complex and inter-individual variability in their topography is high. We applied this method to an example OCD patient case who underwent DBS surgery, formulating an initial proof of concept for a tractography-guided patient-specific approach in DBS for medically intractable OCD. This may improve on current surgical practice, which involves implanting all patients at identical stereotactic coordinates within the VC/VS region. |
| first_indexed | 2024-09-23T13:13:57Z |
| format | Article |
| id | mit-1721.1/106645 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T13:13:57Z |
| publishDate | 2017 |
| publisher | Springer US |
| record_format | dspace |
| spelling | mit-1721.1/1066452022-10-01T13:53:44Z Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD) Makris, Nikolaos Rathi, Yogesh Mouradian, Palig Bonmassar, Giorgio Papadimitriou, George Kubicki, Marek Fan, Qiuyun Nummenmaa, Aapo Ing, Wingkwai I. Yeterian, Edward H. Eskandar, Emad N. Wald, Lawrence L. Dougherty, Darin D. Widge, Alik Picower Institute for Learning and Memory Widge, Alik Deep Brain Stimulation (DBS) is a neurosurgical procedure that can reduce symptoms in medically intractable obsessive-compulsive disorder (OCD). Conceptually, DBS of the ventral capsule/ventral striatum (VC/VS) region targets reciprocal excitatory connections between the orbitofrontal cortex (OFC) and thalamus, decreasing abnormal reverberant activity within the OFC-caudate-pallidal-thalamic circuit. In this study, we investigated these connections using diffusion magnetic resonance imaging (dMRI) on human connectome datasets of twenty-nine healthy young-adult volunteers with two-tensor unscented Kalman filter based tractography. We studied the morphology of the lateral and medial orbitofrontothalamic connections and estimated their topographic variability within the VC/VS region. Our results showed that the morphology of the individual orbitofrontothalamic fibers of passage in the VC/VS region is complex and inter-individual variability in their topography is high. We applied this method to an example OCD patient case who underwent DBS surgery, formulating an initial proof of concept for a tractography-guided patient-specific approach in DBS for medically intractable OCD. This may improve on current surgical practice, which involves implanting all patients at identical stereotactic coordinates within the VC/VS region. 2017-01-26T23:08:53Z 2017-01-26T23:08:53Z 2015-10 2016-08-18T15:46:10Z Article http://purl.org/eprint/type/JournalArticle 1931-7557 1931-7565 http://hdl.handle.net/1721.1/106645 Makris, Nikolaos, Yogesh Rathi, Palig Mouradian, Giorgio Bonmassar, George Papadimitriou, Wingkwai I. Ing, Edward H. Yeterian, et al. “Variability and Anatomical Specificity of the Orbitofrontothalamic Fibers of Passage in the Ventral Capsule/ventral Striatum (VC/VS): Precision Care for Patient-Specific Tractography-Guided Targeting of Deep Brain Stimulation (DBS) in Obsessive Compulsive Disorder (OCD).” Brain Imaging and Behavior (October 30, 2015). https://orcid.org/0000-0001-8510-341X en http://dx.doi.org/10.1007/s11682-015-9462-9 Brain Imaging and Behavior Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. Springer Science+Business Media New York application/pdf Springer US Springer US |
| spellingShingle | Makris, Nikolaos Rathi, Yogesh Mouradian, Palig Bonmassar, Giorgio Papadimitriou, George Kubicki, Marek Fan, Qiuyun Nummenmaa, Aapo Ing, Wingkwai I. Yeterian, Edward H. Eskandar, Emad N. Wald, Lawrence L. Dougherty, Darin D. Widge, Alik Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD) |
| title | Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD) |
| title_full | Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD) |
| title_fullStr | Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD) |
| title_full_unstemmed | Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD) |
| title_short | Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD) |
| title_sort | variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule ventral striatum vc vs precision care for patient specific tractography guided targeting of deep brain stimulation dbs in obsessive compulsive disorder ocd |
| url | http://hdl.handle.net/1721.1/106645 https://orcid.org/0000-0001-8510-341X |
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