Modeling the effect of dendritic input location on MEG and EEG source dipoles
The cerebral sources of magneto- and electroencephalography (MEG, EEG) signals can be represented by current dipoles. We used computational modeling of realistically shaped passive-membrane dendritic trees of pyramidal cells from the human cerebral cortex to examine how the spatial distribution of t...
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| Format: | Article |
| Language: | English |
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Springer Berlin Heidelberg
2017
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| Online Access: | http://hdl.handle.net/1721.1/106661 |
| _version_ | 1811093184086802432 |
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| author | Wreh, Christopher Ahlfors, Seppo Pentti |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Wreh, Christopher Ahlfors, Seppo Pentti |
| author_sort | Wreh, Christopher |
| collection | MIT |
| description | The cerebral sources of magneto- and electroencephalography (MEG, EEG) signals can be represented by current dipoles. We used computational modeling of realistically shaped passive-membrane dendritic trees of pyramidal cells from the human cerebral cortex to examine how the spatial distribution of the synaptic inputs affects the current dipole. The magnitude of the total dipole moment vector was found to be proportional to the vertical location of the synaptic input. The dipole moment had opposite directions for inputs above and below a reversal point located near the soma. Inclusion of shunting-type inhibition either suppressed or enhanced the current dipole, depending on whether the excitatory and inhibitory synapses were on the same or opposite side of the reversal point. Relating the properties of the macroscopic current dipoles to dendritic current distributions can help to provide means for interpreting MEG and EEG data in terms of synaptic connection patterns within cortical areas. |
| first_indexed | 2024-09-23T15:41:00Z |
| format | Article |
| id | mit-1721.1/106661 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:41:00Z |
| publishDate | 2017 |
| publisher | Springer Berlin Heidelberg |
| record_format | dspace |
| spelling | mit-1721.1/1066612022-10-02T03:26:02Z Modeling the effect of dendritic input location on MEG and EEG source dipoles Wreh, Christopher Ahlfors, Seppo Pentti Massachusetts Institute of Technology. Institute for Medical Engineering & Science Harvard University--MIT Division of Health Sciences and Technology Ahlfors, Seppo Pentti The cerebral sources of magneto- and electroencephalography (MEG, EEG) signals can be represented by current dipoles. We used computational modeling of realistically shaped passive-membrane dendritic trees of pyramidal cells from the human cerebral cortex to examine how the spatial distribution of the synaptic inputs affects the current dipole. The magnitude of the total dipole moment vector was found to be proportional to the vertical location of the synaptic input. The dipole moment had opposite directions for inputs above and below a reversal point located near the soma. Inclusion of shunting-type inhibition either suppressed or enhanced the current dipole, depending on whether the excitatory and inhibitory synapses were on the same or opposite side of the reversal point. Relating the properties of the macroscopic current dipoles to dendritic current distributions can help to provide means for interpreting MEG and EEG data in terms of synaptic connection patterns within cortical areas. National Center for Research Resources (U.S.) (P41RR14075) National Institutes of Health (U.S.) (Grants NS57500 and NS037462) 2017-01-27T20:34:58Z 2017-01-27T20:34:58Z 2015-04 2014-05 2016-08-18T15:36:54Z Article http://purl.org/eprint/type/JournalArticle 0140-0118 1741-0444 http://hdl.handle.net/1721.1/106661 Ahlfors, Seppo P., and Christopher Wreh. “Modeling the Effect of Dendritic Input Location on MEG and EEG Source Dipoles.” Medical & Biological Engineering & Computing 53, no. 9 (April 12, 2015): 879–887. en http://dx.doi.org/10.1007/s11517-015-1296-5 Medical & Biological Engineering & Computing Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. International Federation for Medical and Biological Engineering application/pdf Springer Berlin Heidelberg Springer Berlin Heidelberg |
| spellingShingle | Wreh, Christopher Ahlfors, Seppo Pentti Modeling the effect of dendritic input location on MEG and EEG source dipoles |
| title | Modeling the effect of dendritic input location on MEG and EEG source dipoles |
| title_full | Modeling the effect of dendritic input location on MEG and EEG source dipoles |
| title_fullStr | Modeling the effect of dendritic input location on MEG and EEG source dipoles |
| title_full_unstemmed | Modeling the effect of dendritic input location on MEG and EEG source dipoles |
| title_short | Modeling the effect of dendritic input location on MEG and EEG source dipoles |
| title_sort | modeling the effect of dendritic input location on meg and eeg source dipoles |
| url | http://hdl.handle.net/1721.1/106661 |
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