On the efficiency and accuracy of the single equivalent moving dipole method to identify sites of cardiac electrical activation
We have proposed an algorithm to guide radiofrequency catheter ablation procedures. This algorithm employs the single equivalent moving dipole (SEMD) to model cardiac electrical activity. The aim of this study is to investigate the optimal time instant during the cardiac cycle as well as the number...
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| Format: | Article |
| Language: | English |
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Springer Berlin Heidelberg
2017
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| Online Access: | http://hdl.handle.net/1721.1/106663 |
| _version_ | 1826205352949972992 |
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| author | Sohn, Kwanghyun Armoundas, Antonis |
| author2 | Institute for Medical Engineering and Science |
| author_facet | Institute for Medical Engineering and Science Sohn, Kwanghyun Armoundas, Antonis |
| author_sort | Sohn, Kwanghyun |
| collection | MIT |
| description | We have proposed an algorithm to guide radiofrequency catheter ablation procedures. This algorithm employs the single equivalent moving dipole (SEMD) to model cardiac electrical activity. The aim of this study is to investigate the optimal time instant during the cardiac cycle as well as the number of beats needed to accurately estimate the location of a pacing site. We have evaluated this algorithm by pacing the ventricular epicardial surface and inversely estimating the locations of pacing electrodes from the recorded body surface potentials. Two pacing electrode arrays were sutured on the right and left ventricular epicardial surfaces in swine. The hearts were paced by the electrodes sequentially at multiple rates (120–220 bpm), and body surface ECG signals from 64 leads were recorded for the SEMD estimation. We evaluated the combined error of the estimated interelectrode distance and SEMD direction at each time instant during the cardiac cycle, and found the error was minimum when the normalized root mean square (RMS[subscript n]) value of body surface ECG signals reached 15 % of its maximum value. The beat-to-beat variation of the SEMD locations was significantly reduced (p < 0.001) when estimated at 15 % RMS[subscript n] compared to the earliest activation time (EAT). In addition, the 5–95 % interval of the estimated interelectrode distance error decreased exponentially as the number of beats used to estimate a median beat increased. When the number of beats was 4 or larger, the 5–95 % interval was smaller than 3.5 mm (the diameter of a commonly used catheter). In conclusion, the optimal time for the SEMD estimation is at 15 % of RMS[subscript n], and at that time instant a median beat estimated from 4 beats is associated with a beat-to-beat variability of the SEMD location that is appropriate for catheter ablation procedures. |
| first_indexed | 2024-09-23T13:11:39Z |
| format | Article |
| id | mit-1721.1/106663 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T13:11:39Z |
| publishDate | 2017 |
| publisher | Springer Berlin Heidelberg |
| record_format | dspace |
| spelling | mit-1721.1/1066632022-10-01T13:41:24Z On the efficiency and accuracy of the single equivalent moving dipole method to identify sites of cardiac electrical activation Sohn, Kwanghyun Armoundas, Antonis Institute for Medical Engineering and Science Armoundas, Antonis We have proposed an algorithm to guide radiofrequency catheter ablation procedures. This algorithm employs the single equivalent moving dipole (SEMD) to model cardiac electrical activity. The aim of this study is to investigate the optimal time instant during the cardiac cycle as well as the number of beats needed to accurately estimate the location of a pacing site. We have evaluated this algorithm by pacing the ventricular epicardial surface and inversely estimating the locations of pacing electrodes from the recorded body surface potentials. Two pacing electrode arrays were sutured on the right and left ventricular epicardial surfaces in swine. The hearts were paced by the electrodes sequentially at multiple rates (120–220 bpm), and body surface ECG signals from 64 leads were recorded for the SEMD estimation. We evaluated the combined error of the estimated interelectrode distance and SEMD direction at each time instant during the cardiac cycle, and found the error was minimum when the normalized root mean square (RMS[subscript n]) value of body surface ECG signals reached 15 % of its maximum value. The beat-to-beat variation of the SEMD locations was significantly reduced (p < 0.001) when estimated at 15 % RMS[subscript n] compared to the earliest activation time (EAT). In addition, the 5–95 % interval of the estimated interelectrode distance error decreased exponentially as the number of beats used to estimate a median beat increased. When the number of beats was 4 or larger, the 5–95 % interval was smaller than 3.5 mm (the diameter of a commonly used catheter). In conclusion, the optimal time for the SEMD estimation is at 15 % of RMS[subscript n], and at that time instant a median beat estimated from 4 beats is associated with a beat-to-beat variability of the SEMD location that is appropriate for catheter ablation procedures. National Institutes of Health (U.S.) (grant 1RO1HL103961) 2017-01-27T21:01:38Z 2017-01-27T21:01:38Z 2016-01 2015-06 2016-08-18T15:36:49Z Article http://purl.org/eprint/type/JournalArticle 0140-0118 1741-0444 http://hdl.handle.net/1721.1/106663 Sohn, Kwanghyun, and Antonis A. Armoundas. “On the Efficiency and Accuracy of the Single Equivalent Moving Dipole Method to Identify Sites of Cardiac Electrical Activation.” Medical & Biological Engineering & Computing 54, no. 10 (January 22, 2016): 1611–1619. en http://dx.doi.org/10.1007/s11517-015-1437-x Medical & Biological Engineering & Computing Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. International Federation for Medical and Biological Engineering application/pdf Springer Berlin Heidelberg Springer Berlin Heidelberg |
| spellingShingle | Sohn, Kwanghyun Armoundas, Antonis On the efficiency and accuracy of the single equivalent moving dipole method to identify sites of cardiac electrical activation |
| title | On the efficiency and accuracy of the single equivalent moving dipole method to identify sites of cardiac electrical activation |
| title_full | On the efficiency and accuracy of the single equivalent moving dipole method to identify sites of cardiac electrical activation |
| title_fullStr | On the efficiency and accuracy of the single equivalent moving dipole method to identify sites of cardiac electrical activation |
| title_full_unstemmed | On the efficiency and accuracy of the single equivalent moving dipole method to identify sites of cardiac electrical activation |
| title_short | On the efficiency and accuracy of the single equivalent moving dipole method to identify sites of cardiac electrical activation |
| title_sort | on the efficiency and accuracy of the single equivalent moving dipole method to identify sites of cardiac electrical activation |
| url | http://hdl.handle.net/1721.1/106663 |
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