Proton pump inhibitor use is not associated with cardiac arrhythmia in critically ill patients
Hypomagnesemia can lead to cardiac arrythmias. Recently, observational data have linked chronic proton pump inhibitor (PPI) exposure to hypomagnesemia. Whether PPI exposure increases the risk for arrhythmias has not been well studied. Using a large, single-center inception cohort of critically ill p...
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| Format: | Article |
| Language: | en_US |
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John Wiley & Sons, Inc.
2017
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| Online Access: | http://hdl.handle.net/1721.1/106815 https://orcid.org/0000-0001-8593-9321 https://orcid.org/0000-0002-6318-2978 |
| _version_ | 1811091594913251328 |
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| author | Chen, Kenneth P. Malley, Brian E. Danziger, John Lee, Joonwu Mark, Roger G Feng, Mengling Celi, Leo Anthony G. |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Chen, Kenneth P. Malley, Brian E. Danziger, John Lee, Joonwu Mark, Roger G Feng, Mengling Celi, Leo Anthony G. |
| author_sort | Chen, Kenneth P. |
| collection | MIT |
| description | Hypomagnesemia can lead to cardiac arrythmias. Recently, observational data have linked chronic proton pump inhibitor (PPI) exposure to hypomagnesemia. Whether PPI exposure increases the risk for arrhythmias has not been well studied. Using a large, single-center inception cohort of critically ill patients, we examined whether PPI exposure was associated with admission electrocardiogram readings of a cardiac arrhythmia in more than 8000 patients. There were 25.4% PPI users, whereas 6% were taking a histamine 2 antagonist. In all, 14.0% had a cardiac arrhythmia. PPI use was associated with an unadjusted risk of arrhythmia of 1.15 (95% CI,1.00–1.32; P =.04) and an adjusted risk of arrhythmia of 0.91 (95% CI, 0.77–1.06; P =.22). Among diuretic users (n = 2476), PPI use was similarly not associated with an increased risk of cardiac arrhythmia. In summary, in a large cohort of critically ill patients, PPI exposure is not associated with an increased risk of cardiac arrhythmia. |
| first_indexed | 2024-09-23T15:04:52Z |
| format | Article |
| id | mit-1721.1/106815 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:04:52Z |
| publishDate | 2017 |
| publisher | John Wiley & Sons, Inc. |
| record_format | dspace |
| spelling | mit-1721.1/1068152022-09-29T12:34:40Z Proton pump inhibitor use is not associated with cardiac arrhythmia in critically ill patients Chen, Kenneth P. Malley, Brian E. Danziger, John Lee, Joonwu Mark, Roger G Feng, Mengling Celi, Leo Anthony G. Massachusetts Institute of Technology. Institute for Medical Engineering & Science Harvard University--MIT Division of Health Sciences and Technology Mark, Roger G Lee, Joonwu Mark, Roger G Feng, Mengling Celi, Leo Anthony G. Hypomagnesemia can lead to cardiac arrythmias. Recently, observational data have linked chronic proton pump inhibitor (PPI) exposure to hypomagnesemia. Whether PPI exposure increases the risk for arrhythmias has not been well studied. Using a large, single-center inception cohort of critically ill patients, we examined whether PPI exposure was associated with admission electrocardiogram readings of a cardiac arrhythmia in more than 8000 patients. There were 25.4% PPI users, whereas 6% were taking a histamine 2 antagonist. In all, 14.0% had a cardiac arrhythmia. PPI use was associated with an unadjusted risk of arrhythmia of 1.15 (95% CI,1.00–1.32; P =.04) and an adjusted risk of arrhythmia of 0.91 (95% CI, 0.77–1.06; P =.22). Among diuretic users (n = 2476), PPI use was similarly not associated with an increased risk of cardiac arrhythmia. In summary, in a large cohort of critically ill patients, PPI exposure is not associated with an increased risk of cardiac arrhythmia. National Institutes of Health (U.S.) (NIH Grant R01 EB017205) 2017-01-31T19:12:03Z 2017-01-31T19:12:03Z 2015-03 2015-02 Article http://purl.org/eprint/type/JournalArticle 00912700 http://hdl.handle.net/1721.1/106815 Chen, K. P., Lee, J., Mark, R. G., Feng, M., Celi, L. A., Malley, B. E. and Danziger, J. (2015), "Proton pump inhibitor use is not associated with cardiac arrhythmia in critically ill patients." Journal of Clinical Pharmacology, 55: 774-779. https://orcid.org/0000-0001-8593-9321 https://orcid.org/0000-0002-6318-2978 en_US http://dx.doi.org/10.1002/jcph.479 Journal of Clinical Pharmacology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf John Wiley & Sons, Inc. Prof. Mark via Courtney Crummett |
| spellingShingle | Chen, Kenneth P. Malley, Brian E. Danziger, John Lee, Joonwu Mark, Roger G Feng, Mengling Celi, Leo Anthony G. Proton pump inhibitor use is not associated with cardiac arrhythmia in critically ill patients |
| title | Proton pump inhibitor use is not associated with cardiac arrhythmia in critically ill patients |
| title_full | Proton pump inhibitor use is not associated with cardiac arrhythmia in critically ill patients |
| title_fullStr | Proton pump inhibitor use is not associated with cardiac arrhythmia in critically ill patients |
| title_full_unstemmed | Proton pump inhibitor use is not associated with cardiac arrhythmia in critically ill patients |
| title_short | Proton pump inhibitor use is not associated with cardiac arrhythmia in critically ill patients |
| title_sort | proton pump inhibitor use is not associated with cardiac arrhythmia in critically ill patients |
| url | http://hdl.handle.net/1721.1/106815 https://orcid.org/0000-0001-8593-9321 https://orcid.org/0000-0002-6318-2978 |
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