Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport

Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport

Nucleoporin-like polypeptide (NLP) hydrogels are developed by mimicking nucleoporins, proteins that form gel filters regulating transport into the nucleus. Using protein polymers of a minimal consensus repeat, the NLPs selectively enhance transport of cargo–carrier complexes similar to the natural n...

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Bibliographic Details
Main Authors: Kim, Minkyu, Chen, Wesley George, Ribbeck, Katharina, Olsen, Bradley D, Kang, Jeon Woong, Glassman, Matthew J.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Wiley Blackwell 2017
Online Access:http://hdl.handle.net/1721.1/106834
https://orcid.org/0000-0002-9476-6351
https://orcid.org/0000-0003-1646-2456
https://orcid.org/0000-0001-8260-338X
https://orcid.org/0000-0002-7272-7140
Description
Summary:Nucleoporin-like polypeptide (NLP) hydrogels are developed by mimicking nucleoporins, proteins that form gel filters regulating transport into the nucleus. Using protein polymers of a minimal consensus repeat, the NLPs selectively enhance transport of cargo–carrier complexes similar to the natural nuclear pore system. The engineered protein gels additionally have tunable mechanical and transport properties and can be biosynthesized at high yield, making them promising materials for advanced separation technologies.

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