Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake

Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake

We report a new series of 8-membered benzo-fused lactams that inhibit cellular lipid uptake from HDL particles mediated by Scavenger Receptor, Class B, Type I (SR-BI). The series was identified via a high-throughput screen of the National Institutes of Health Molecular Libraries Small Molecule Repos...

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Bibliographic Details
Main Authors:	Dockendorff, Chris, Faloon, Patrick W., Pu, Jun, Johnston, Stephen, Bennion, Melissa, Dandapani, Sivaraman, Perez, José R., Munoz, Benito, Palmer, Michelle A., Schreiber, Stuart L., Yu, Miao, Penman, Marsha L, Nieland, Thomas J, Krieger, Monty
Other Authors:	Massachusetts Institute of Technology. Department of Biology
Format:	Article
Language:	en_US
Published:	Elsevier 2017
Online Access:	http://hdl.handle.net/1721.1/106851 https://orcid.org/0000-0003-2673-1672 https://orcid.org/0000-0003-4541-5181

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