Modular combinatorial binding among human trans-acting factors reveals direct and indirect factor binding
Background The combinatorial binding of trans-acting factors (TFs) to the DNA is critical to the spatial and temporal specificity of gene regulation. For certain regulatory regions, more than one regulatory module (set of TFs that bind together) are combined to achieve context-specific gene regulat...
Main Authors: | Guo, Yuchun, Gifford, David K |
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Other Authors: | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory |
Format: | Article |
Language: | English |
Published: |
BioMed Central
2017
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Online Access: | http://hdl.handle.net/1721.1/106853 https://orcid.org/0000-0003-2357-1546 https://orcid.org/0000-0003-1709-4034 |
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