Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo

Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo

Safe and effective delivery is required for siRNA and mRNA-based therapeutics to reach their potential. Here, we report on the development of poly(glycoamidoamine) brush nanoparticles as delivery vehicles for siRNA and mRNA. These polymers were capable of significant delivery of siRNA against FVII a...

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Bibliographic Details
Main Authors: Abutbul-Ionita, Inbal, Danino, Dganit, DeRosa, Frank, Heartlein, Michael, Dong, Yizhou, Dorkin, Joseph Robert, Wang, Weiheng, Webber, Matthew, Tang, Benjamin C., Yang, Jung H, Langer, Robert S, Anderson, Daniel Griffith, Chang, Philip H.
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2017
Online Access:http://hdl.handle.net/1721.1/107111
https://orcid.org/0000-0001-5786-0659
https://orcid.org/0000-0003-3298-6022
https://orcid.org/0000-0003-0624-3532
https://orcid.org/0000-0003-4255-0492
https://orcid.org/0000-0001-5629-4798

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