High throughput screening for discovery of materials that control stem cell fate
Insights into the complex stem cell niche have identified the cell–material interface to be a potent regulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this, materials scientists have the opportunity to develop bioactive materials for stem ce...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2017
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| Online Access: | http://hdl.handle.net/1721.1/107190 https://orcid.org/0000-0002-7266-9251 https://orcid.org/0000-0002-4917-7187 https://orcid.org/0000-0003-4255-0492 https://orcid.org/0000-0001-5629-4798 |
| _version_ | 1811073459106611200 |
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| author | Celiz, Adam D. Davies, Martyn C. Denning, Chris Alexander, Morgan R. Tibbitt, Mark W Langer, Robert S Anderson, Daniel Griffith Patel, Asha |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Celiz, Adam D. Davies, Martyn C. Denning, Chris Alexander, Morgan R. Tibbitt, Mark W Langer, Robert S Anderson, Daniel Griffith Patel, Asha |
| author_sort | Celiz, Adam D. |
| collection | MIT |
| description | Insights into the complex stem cell niche have identified the cell–material interface to be a potent regulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this, materials scientists have the opportunity to develop bioactive materials for stem cell culture that elicit specific cellular responses. To accelerate materials discovery, high throughput screening platforms have been designed which can rapidly evaluate combinatorial material libraries in two and three-dimensional environments. In this review, we present screening platforms for the discovery of material properties that influence stem cell behavior. |
| first_indexed | 2024-09-23T09:33:26Z |
| format | Article |
| id | mit-1721.1/107190 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:33:26Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1071902022-09-30T15:16:55Z High throughput screening for discovery of materials that control stem cell fate Celiz, Adam D. Davies, Martyn C. Denning, Chris Alexander, Morgan R. Tibbitt, Mark W Langer, Robert S Anderson, Daniel Griffith Patel, Asha Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT Patel, Asha K Tibbitt, Mark W Langer, Robert S Anderson, Daniel Griffith Insights into the complex stem cell niche have identified the cell–material interface to be a potent regulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this, materials scientists have the opportunity to develop bioactive materials for stem cell culture that elicit specific cellular responses. To accelerate materials discovery, high throughput screening platforms have been designed which can rapidly evaluate combinatorial material libraries in two and three-dimensional environments. In this review, we present screening platforms for the discovery of material properties that influence stem cell behavior. Engineering and Physical Sciences Research Council National Institutes of Health (U.S.) (Ruth L. Kirschstein National Research Service Award F32HL122009) National Institutes of Health (U.S.) (Grant R01 DE016516) 2017-03-06T16:05:06Z 2017-03-06T16:05:06Z 2016-01 2015-12 Article http://purl.org/eprint/type/JournalArticle 1359-0286 http://hdl.handle.net/1721.1/107190 Patel, Asha K. et al. “High Throughput Screening for Discovery of Materials That Control Stem Cell Fate.” Current Opinion in Solid State and Materials Science 20.4 (2016): 202–211. https://orcid.org/0000-0002-7266-9251 https://orcid.org/0000-0002-4917-7187 https://orcid.org/0000-0003-4255-0492 https://orcid.org/0000-0001-5629-4798 en_US http://dx.doi.org/10.1016/j.cossms.2016.02.002 Current Opinion in Solid State and Materials Science Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Elsevier Elsevier |
| spellingShingle | Celiz, Adam D. Davies, Martyn C. Denning, Chris Alexander, Morgan R. Tibbitt, Mark W Langer, Robert S Anderson, Daniel Griffith Patel, Asha High throughput screening for discovery of materials that control stem cell fate |
| title | High throughput screening for discovery of materials that control stem cell fate |
| title_full | High throughput screening for discovery of materials that control stem cell fate |
| title_fullStr | High throughput screening for discovery of materials that control stem cell fate |
| title_full_unstemmed | High throughput screening for discovery of materials that control stem cell fate |
| title_short | High throughput screening for discovery of materials that control stem cell fate |
| title_sort | high throughput screening for discovery of materials that control stem cell fate |
| url | http://hdl.handle.net/1721.1/107190 https://orcid.org/0000-0002-7266-9251 https://orcid.org/0000-0002-4917-7187 https://orcid.org/0000-0003-4255-0492 https://orcid.org/0000-0001-5629-4798 |
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