Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits
Effective immunity requires a complex network of cellular and humoral components that interact with each other and are influenced by different environmental and host factors. We used a systems biology approach to comprehensively assess the impact of environmental and genetic factors on immune cell p...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2017
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| Online Access: | http://hdl.handle.net/1721.1/107228 |
| _version_ | 1811077700738088960 |
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| author | Aguirre-Gamboa, Raul Joosten, Irma Urbano, Paulo C.M. van der Molen, Renate G. van Rijssen, Esther van Cranenbroek, Bram Oosting, Marije Smeekens, Sanne Jaeger, Martin Zorro, Maria Withoff, Sebo van Herwaarden, Antonius E. Sweep, Fred C.G.J. Netea, Romana T. Swertz, Morris A. Franke, Lude Joosten, Leo A.B. Netea, Mihai G. Wijmenga, Cisca Kumar, Vinod Li, Yang Koenen, Hans J.P.M. Xavier, Ramnik Joseph |
| author2 | Institute for Medical Engineering and Science |
| author_facet | Institute for Medical Engineering and Science Aguirre-Gamboa, Raul Joosten, Irma Urbano, Paulo C.M. van der Molen, Renate G. van Rijssen, Esther van Cranenbroek, Bram Oosting, Marije Smeekens, Sanne Jaeger, Martin Zorro, Maria Withoff, Sebo van Herwaarden, Antonius E. Sweep, Fred C.G.J. Netea, Romana T. Swertz, Morris A. Franke, Lude Joosten, Leo A.B. Netea, Mihai G. Wijmenga, Cisca Kumar, Vinod Li, Yang Koenen, Hans J.P.M. Xavier, Ramnik Joseph |
| author_sort | Aguirre-Gamboa, Raul |
| collection | MIT |
| description | Effective immunity requires a complex network of cellular and humoral components that interact with each other and are influenced by different environmental and host factors. We used a systems biology approach to comprehensively assess the impact of environmental and genetic factors on immune cell populations in peripheral blood, including associations with immunoglobulin concentrations, from ∼500 healthy volunteers from the Human Functional Genomics Project. Genetic heritability estimation showed that variations in T cell numbers are more strongly driven by genetic factors, while B cell counts are more environmentally influenced. Quantitative trait loci (QTL) mapping identified eight independent genomic loci associated with leukocyte count variation, including four associations with T and B cell subtypes. The QTLs identified were enriched among genome-wide association study (GWAS) SNPs reported to increase susceptibility to immune-mediated diseases. Our systems approach provides insights into cellular and humoral immune trait variability in humans. |
| first_indexed | 2024-09-23T10:47:11Z |
| format | Article |
| id | mit-1721.1/107228 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:47:11Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1072282022-09-27T15:00:28Z Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits Aguirre-Gamboa, Raul Joosten, Irma Urbano, Paulo C.M. van der Molen, Renate G. van Rijssen, Esther van Cranenbroek, Bram Oosting, Marije Smeekens, Sanne Jaeger, Martin Zorro, Maria Withoff, Sebo van Herwaarden, Antonius E. Sweep, Fred C.G.J. Netea, Romana T. Swertz, Morris A. Franke, Lude Joosten, Leo A.B. Netea, Mihai G. Wijmenga, Cisca Kumar, Vinod Li, Yang Koenen, Hans J.P.M. Xavier, Ramnik Joseph Institute for Medical Engineering and Science Xavier, Ramnik Joseph Effective immunity requires a complex network of cellular and humoral components that interact with each other and are influenced by different environmental and host factors. We used a systems biology approach to comprehensively assess the impact of environmental and genetic factors on immune cell populations in peripheral blood, including associations with immunoglobulin concentrations, from ∼500 healthy volunteers from the Human Functional Genomics Project. Genetic heritability estimation showed that variations in T cell numbers are more strongly driven by genetic factors, while B cell counts are more environmentally influenced. Quantitative trait loci (QTL) mapping identified eight independent genomic loci associated with leukocyte count variation, including four associations with T and B cell subtypes. The QTLs identified were enriched among genome-wide association study (GWAS) SNPs reported to increase susceptibility to immune-mediated diseases. Our systems approach provides insights into cellular and humoral immune trait variability in humans. 2017-03-07T20:39:52Z 2017-03-07T20:39:52Z 2016-11 2016-08 Article http://purl.org/eprint/type/JournalArticle 2211-1247 http://hdl.handle.net/1721.1/107228 Aguirre-Gamboa, Raul et al. “Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits.” Cell Reports 17.9 (2016): 2474–2487. en_US http://dx.doi.org/10.1016/j.celrep.2016.10.053 Cell Reports Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier Elsevier |
| spellingShingle | Aguirre-Gamboa, Raul Joosten, Irma Urbano, Paulo C.M. van der Molen, Renate G. van Rijssen, Esther van Cranenbroek, Bram Oosting, Marije Smeekens, Sanne Jaeger, Martin Zorro, Maria Withoff, Sebo van Herwaarden, Antonius E. Sweep, Fred C.G.J. Netea, Romana T. Swertz, Morris A. Franke, Lude Joosten, Leo A.B. Netea, Mihai G. Wijmenga, Cisca Kumar, Vinod Li, Yang Koenen, Hans J.P.M. Xavier, Ramnik Joseph Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits |
| title | Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits |
| title_full | Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits |
| title_fullStr | Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits |
| title_full_unstemmed | Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits |
| title_short | Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits |
| title_sort | differential effects of environmental and genetic factors on t and b cell immune traits |
| url | http://hdl.handle.net/1721.1/107228 |
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