Molecular fMRI
Comprehensive analysis of brain function depends on understanding the dynamics of diverse neural signaling processes over large tissue volumes in intact animals and humans. Most existing approaches to measuring brain signaling suffer from limited tissue penetration, poor resolution, or lack of speci...
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| Format: | Article |
| Language: | en_US |
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Society for Neuroscience
2017
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| Online Access: | http://hdl.handle.net/1721.1/107239 https://orcid.org/0000-0002-5044-369X https://orcid.org/0000-0003-4092-7559 https://orcid.org/0000-0002-2834-6359 |
| _version_ | 1811096725170946048 |
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| author | Barandov, Ali Jasanoff, Alan Pradip Bartelle, Benjamin B. |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Barandov, Ali Jasanoff, Alan Pradip Bartelle, Benjamin B. |
| author_sort | Barandov, Ali |
| collection | MIT |
| description | Comprehensive analysis of brain function depends on understanding the dynamics of diverse neural signaling processes over large tissue volumes in intact animals and humans. Most existing approaches to measuring brain signaling suffer from limited tissue penetration, poor resolution, or lack of specificity for well-defined neural events. Here we discuss a new brain activity mapping method that overcomes some of these problems by combining MRI with contrast agents sensitive to neural signaling. The goal of this “molecular fMRI” approach is to permit noninvasive whole-brain neuroimaging with specificity and resolution approaching current optical neuroimaging methods. In this article, we describe the context and need for molecular fMRI as well as the state of the technology today. We explain how major types of MRI probes work and how they can be sensitized to neurobiological processes, such as neurotransmitter release, calcium signaling, and gene expression changes. We comment both on past work in the field and on challenges and promising avenues for future development. |
| first_indexed | 2024-09-23T16:48:03Z |
| format | Article |
| id | mit-1721.1/107239 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:48:03Z |
| publishDate | 2017 |
| publisher | Society for Neuroscience |
| record_format | dspace |
| spelling | mit-1721.1/1072392023-02-26T02:25:09Z Molecular fMRI Barandov, Ali Jasanoff, Alan Pradip Bartelle, Benjamin B. Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Massachusetts Institute of Technology. Department of Nuclear Science and Engineering Bartelle, Benjamin Barandov, Ali Jasanoff, Alan Pradip Comprehensive analysis of brain function depends on understanding the dynamics of diverse neural signaling processes over large tissue volumes in intact animals and humans. Most existing approaches to measuring brain signaling suffer from limited tissue penetration, poor resolution, or lack of specificity for well-defined neural events. Here we discuss a new brain activity mapping method that overcomes some of these problems by combining MRI with contrast agents sensitive to neural signaling. The goal of this “molecular fMRI” approach is to permit noninvasive whole-brain neuroimaging with specificity and resolution approaching current optical neuroimaging methods. In this article, we describe the context and need for molecular fMRI as well as the state of the technology today. We explain how major types of MRI probes work and how they can be sensitized to neurobiological processes, such as neurotransmitter release, calcium signaling, and gene expression changes. We comment both on past work in the field and on challenges and promising avenues for future development. National Institutes of Health (U.S.) (Grants R21-MH102470 and U01-NS09045) Massachusetts Institute of Technology. Simons Center for the Social Brain (Seed Grant) 2017-03-09T14:34:39Z 2017-03-09T14:34:39Z 2016-04 2016-03 Article http://purl.org/eprint/type/JournalArticle 0270-6474 1529-2401 http://hdl.handle.net/1721.1/107239 Bartelle, B. B., A. Barandov, and A. Jasanoff. “Molecular fMRI.” Journal of Neuroscience 36.15 (2016): 4139–4148. https://orcid.org/0000-0002-5044-369X https://orcid.org/0000-0003-4092-7559 https://orcid.org/0000-0002-2834-6359 en_US http://dx.doi.org/10.1523/jneurosci.4050-15.2016 Journal of Neuroscience Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Society for Neuroscience Society for Neuroscience |
| spellingShingle | Barandov, Ali Jasanoff, Alan Pradip Bartelle, Benjamin B. Molecular fMRI |
| title | Molecular fMRI |
| title_full | Molecular fMRI |
| title_fullStr | Molecular fMRI |
| title_full_unstemmed | Molecular fMRI |
| title_short | Molecular fMRI |
| title_sort | molecular fmri |
| url | http://hdl.handle.net/1721.1/107239 https://orcid.org/0000-0002-5044-369X https://orcid.org/0000-0003-4092-7559 https://orcid.org/0000-0002-2834-6359 |
| work_keys_str_mv | AT barandovali molecularfmri AT jasanoffalanpradip molecularfmri AT bartellebenjaminb molecularfmri |