Tradespace as a decision making tool in bioprocess design
Thesis: S.M. in Engineering and Management, Massachusetts Institute of Technology, School of Engineering, System Design and Management Program, Engineering and Management Program, 2016.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2017
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| Online Access: | http://hdl.handle.net/1721.1/107362 |
| _version_ | 1811090502054838272 |
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| author | Tang, Yu-wen, S.M. Massachusetts Institute of Technology |
| author2 | Andrey Zarur. |
| author_facet | Andrey Zarur. Tang, Yu-wen, S.M. Massachusetts Institute of Technology |
| author_sort | Tang, Yu-wen, S.M. Massachusetts Institute of Technology |
| collection | MIT |
| description | Thesis: S.M. in Engineering and Management, Massachusetts Institute of Technology, School of Engineering, System Design and Management Program, Engineering and Management Program, 2016. |
| first_indexed | 2024-09-23T14:47:10Z |
| format | Thesis |
| id | mit-1721.1/107362 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T14:47:10Z |
| publishDate | 2017 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1073622022-01-12T19:11:51Z Tradespace as a decision making tool in bioprocess design Tang, Yu-wen, S.M. Massachusetts Institute of Technology Andrey Zarur. Massachusetts Institute of Technology. Engineering Systems Division. Massachusetts Institute of Technology. Engineering and Management Program System Design and Management Program. Massachusetts Institute of Technology. Engineering Systems Division. System Design and Management Program Engineering and Management Program. System Design and Management Program. Engineering Systems Division. Thesis: S.M. in Engineering and Management, Massachusetts Institute of Technology, School of Engineering, System Design and Management Program, Engineering and Management Program, 2016. Cataloged from PDF version of thesis. Includes bibliographical references (pages 80-83). The field of systems engineering upholds that fundamental engineering principles exist and are applicable across different domains and contexts. In this thesis, a state-of-the art decision and design evaluation method developed for aerospace systems, Multi-Attribute Tradespace Exploration (MATE) is complemented with Design of Experiments (DoE) and applied for the first time to a bioprocess design problem. The implementation of DoE was necessary due to the high complexity of bioprocess systems, where a design variable (or a reasonably small number of design variables) cannot be easily identified to explain a given attribute of the product or process. DoE not only allows the identification of design variables that most influence a given attribute, but also allows the development of Single-Utility-Functions facilitating the incorporation of the Multi- Utility component of the MATE method. The proposed new MATE-DoE method was implemented in two case studies to assess its applicability; namely bio-production of DHA and bio-production of a lipase enzyme. Based on published DoE experimental results, utility functions and cost estimations were carried out to develop a Tradespace. The resulting Tradespace demonstrates: (a) the possible implementation of the proposed method, (b) that the use of Tradespace complements the traditional bioprocess development practice by allowing decision makers to choose an architecture that optimizes for more than one objective (multi-objective), (c) that the proposed method takes into consideration the complex decision making process of customers (multi-attribute), and (d) that simultaneous comparison analysis to competitors and market standards are possible using the method. While the method was proven to be applicable, it is relatively complex and the number of experiments and market data required might prevent its broad implementation. Also, potential errors and misleading results might result from inaccurate input data. Special attention and effort need to be put in accurate Single-Utility Function (SUF) weight designation to avoid this problem. The importance of assessing the complete bioprocess, as opposed to individual unit operations, is highlighted. Finally, further studies to develop "rules of thumb" in order to simplify the proposed MATE-DoE method is suggested. by Yu-wen Tang. S.M. in Engineering and Management 2017-03-10T15:07:08Z 2017-03-10T15:07:08Z 2016 2016 Thesis http://hdl.handle.net/1721.1/107362 973334332 eng MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. http://dspace.mit.edu/handle/1721.1/7582 94 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Engineering and Management Program. System Design and Management Program. Engineering Systems Division. Tang, Yu-wen, S.M. Massachusetts Institute of Technology Tradespace as a decision making tool in bioprocess design |
| title | Tradespace as a decision making tool in bioprocess design |
| title_full | Tradespace as a decision making tool in bioprocess design |
| title_fullStr | Tradespace as a decision making tool in bioprocess design |
| title_full_unstemmed | Tradespace as a decision making tool in bioprocess design |
| title_short | Tradespace as a decision making tool in bioprocess design |
| title_sort | tradespace as a decision making tool in bioprocess design |
| topic | Engineering and Management Program. System Design and Management Program. Engineering Systems Division. |
| url | http://hdl.handle.net/1721.1/107362 |
| work_keys_str_mv | AT tangyuwensmmassachusettsinstituteoftechnology tradespaceasadecisionmakingtoolinbioprocessdesign |