RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling

RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling

Invading pathogen nucleic acids are recognized and bound by cytoplasmic (retinoic acid-inducible gene I [RIG-I]-like) and membrane-bound (Toll-like) pattern recognition receptors to activate innate immune signaling. Modified nucleotides, when present in RNA molecules, diminish the magnitude of these...

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Bibliographic Details
Main Authors: Durbin, Ann Fiegen, Wang, Chen, Marcotrigiano, Joseph, Gehrke, Lee
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: American Society for Microbiology 2017
Online Access:http://hdl.handle.net/1721.1/107388
https://orcid.org/0000-0002-9387-8212

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