Novel genomic island modifies DNA with 7-deazaguanine derivatives
The discovery of ∼20-kb gene clusters containing a family of paralogs of tRNA guanosine transglycosylase genes, called tgtA5, alongside 7-cyano-7-deazaguanine (preQ[subscript 0]) synthesis and DNA metabolism genes, led to the hypothesis that 7-deazaguanine derivatives are inserted in DNA. This was e...
Main Authors: | Thiaville, Jennifer J., Yuan, Yifeng, Hutinet, Geoffrey, Thiaville, Patrick C., Brochier-Armanet, Celine, Letarov, Andrey V., Malik, Chanchal K., Rizzo, Carmelo J., de Crécy-Lagard, Valérie, Kellner, Stefanie M, Jumpathong, Watthanachai, Mohapatra, Susovan, Hillebrand, Roman, Dedon, Peter C |
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Other Authors: | Massachusetts Institute of Technology. Center for Environmental Health Sciences |
Format: | Article |
Language: | en_US |
Published: |
National Academy of Sciences (U.S.)
2017
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Online Access: | http://hdl.handle.net/1721.1/107419 https://orcid.org/0000-0003-3224-7502 https://orcid.org/0000-0002-1976-8103 https://orcid.org/0000-0001-9357-0077 https://orcid.org/0000-0003-0011-3067 |
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