Stop flow lithography in perfluoropolyether (PFPE) microfluidic channels
Stop Flow Lithography (SFL) is a microfluidic-based particle synthesis method for creating anisotropic multifunctional particles with applications that range from MEMS to biomedical engineering. Polydimethylsiloxane (PDMS) has been typically used to construct SFL devices as the material enables rapi...
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| Format: | Article |
| Language: | en_US |
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Royal Society of Chemistry
2017
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| Online Access: | http://hdl.handle.net/1721.1/107432 |
| _version_ | 1826205837416202240 |
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| author | Doyle, Patrick S Bong, Ki Wan Lee, Jiseok |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Doyle, Patrick S Bong, Ki Wan Lee, Jiseok |
| author_sort | Doyle, Patrick S |
| collection | MIT |
| description | Stop Flow Lithography (SFL) is a microfluidic-based particle synthesis method for creating anisotropic multifunctional particles with applications that range from MEMS to biomedical engineering. Polydimethylsiloxane (PDMS) has been typically used to construct SFL devices as the material enables rapid prototyping of channels with complex geometries, optical transparency, and oxygen permeability. However, PDMS is not compatible with most organic solvents which limit the current range of materials that can be synthesized with SFL. Here, we demonstrate that a fluorinated elastomer, called perfluoropolyether (PFPE), can be an alternative oxygen permeable elastomer for SFL microfluidic flow channels. We fabricate PFPE microfluidic devices with soft lithography and synthesize anisotropic multifunctional particles in the devices via the SFL process – this is the first demonstration of SFL with oxygen lubrication layers in a non-PDMS channel. We benchmark the SFL performance of the PFPE devices by comparing them to PDMS devices. We synthesized particles in both PFPE and PDMS devices under the same SFL conditions and found the difference of particle dimensions was less than a micron. PFPE devices can greatly expand the range of precursor materials that can be processed in SFL because the fluorinated devices are chemically resistant to most organic solvents, an inaccessible class of reagents in PDMS-based devices due to swelling. |
| first_indexed | 2024-09-23T13:19:53Z |
| format | Article |
| id | mit-1721.1/107432 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:19:53Z |
| publishDate | 2017 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | mit-1721.1/1074322022-09-28T13:27:15Z Stop flow lithography in perfluoropolyether (PFPE) microfluidic channels Doyle, Patrick S Bong, Ki Wan Lee, Jiseok Massachusetts Institute of Technology. Department of Chemical Engineering Doyle, Patrick S Bong, Ki Wan Lee, Jiseok Stop Flow Lithography (SFL) is a microfluidic-based particle synthesis method for creating anisotropic multifunctional particles with applications that range from MEMS to biomedical engineering. Polydimethylsiloxane (PDMS) has been typically used to construct SFL devices as the material enables rapid prototyping of channels with complex geometries, optical transparency, and oxygen permeability. However, PDMS is not compatible with most organic solvents which limit the current range of materials that can be synthesized with SFL. Here, we demonstrate that a fluorinated elastomer, called perfluoropolyether (PFPE), can be an alternative oxygen permeable elastomer for SFL microfluidic flow channels. We fabricate PFPE microfluidic devices with soft lithography and synthesize anisotropic multifunctional particles in the devices via the SFL process – this is the first demonstration of SFL with oxygen lubrication layers in a non-PDMS channel. We benchmark the SFL performance of the PFPE devices by comparing them to PDMS devices. We synthesized particles in both PFPE and PDMS devices under the same SFL conditions and found the difference of particle dimensions was less than a micron. PFPE devices can greatly expand the range of precursor materials that can be processed in SFL because the fluorinated devices are chemically resistant to most organic solvents, an inaccessible class of reagents in PDMS-based devices due to swelling. Kwanjeong Educational Foundation (Korea) Singapore-MIT Alliance for Research and Technology (SMART) National Science Foundation (U.S.) (Grants CMMI-1120724 and DMR- 1006147) 2017-03-16T14:24:55Z 2017-03-16T14:24:55Z 2014-10 2014-07 Article http://purl.org/eprint/type/JournalArticle 1473-0197 1473-0189 http://hdl.handle.net/1721.1/107432 Bong, Ki Wan, Jiseok Lee, and Patrick S. Doyle. “Stop Flow Lithography in Perfluoropolyether (PFPE) Microfluidic Channels.” Lab on a Chip 14.24 (2014): 4680–4687. en_US http://dx.doi.org/10.1039/c4lc00877d Lab on a Chip Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Royal Society of Chemistry MIT Web Domain |
| spellingShingle | Doyle, Patrick S Bong, Ki Wan Lee, Jiseok Stop flow lithography in perfluoropolyether (PFPE) microfluidic channels |
| title | Stop flow lithography in perfluoropolyether (PFPE) microfluidic channels |
| title_full | Stop flow lithography in perfluoropolyether (PFPE) microfluidic channels |
| title_fullStr | Stop flow lithography in perfluoropolyether (PFPE) microfluidic channels |
| title_full_unstemmed | Stop flow lithography in perfluoropolyether (PFPE) microfluidic channels |
| title_short | Stop flow lithography in perfluoropolyether (PFPE) microfluidic channels |
| title_sort | stop flow lithography in perfluoropolyether pfpe microfluidic channels |
| url | http://hdl.handle.net/1721.1/107432 |
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