Synthesis of Nonspherical Microcapsules through Controlled Polyelectrolyte Coating of Hydrogel Templates
We report a simple approach to fabricate custom-shape microcapsules using hydrogel templates synthesized by stop flow lithography. Cargo-containing microcapsules were made by coating hydrogel particles with a single layer of poly-l-lysine followed by a one-step core degradation and capsule cross-lin...
| Main Authors: | , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
American Chemical Society (ACS)
2017
|
| Online Access: | http://hdl.handle.net/1721.1/107434 https://orcid.org/0000-0002-2505-3657 |
| _version_ | 1826197735931379712 |
|---|---|
| author | Chen, Lynna An, Harry Doyle, Patrick S |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Chen, Lynna An, Harry Doyle, Patrick S |
| author_sort | Chen, Lynna |
| collection | MIT |
| description | We report a simple approach to fabricate custom-shape microcapsules using hydrogel templates synthesized by stop flow lithography. Cargo-containing microcapsules were made by coating hydrogel particles with a single layer of poly-l-lysine followed by a one-step core degradation and capsule cross-linking procedure. We determined appropriate coating conditions by investigating the effect of pH, ionic strength, and prepolymer composition on the diffusion of polyelectrolytes into the oppositely charged hydrogel template. We also characterized the degradation of the templating core by tracking the diffusivity of nanoparticles embedded within the hydrogel. Unlike any other technique, this approach allows for easy fabrication of microcapsules with internal features (e.g., toroids) and selective surface modification of Janus particles using any polyelectrolyte. These soft, flexible capsules may be useful for therapeutic applications as well as fundamental studies of membrane mechanics. |
| first_indexed | 2024-09-23T10:52:21Z |
| format | Article |
| id | mit-1721.1/107434 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:52:21Z |
| publishDate | 2017 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1074342022-09-27T15:36:58Z Synthesis of Nonspherical Microcapsules through Controlled Polyelectrolyte Coating of Hydrogel Templates Chen, Lynna An, Harry Doyle, Patrick S Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Chemical Engineering Chen, Lynna An, Harry Doyle, Patrick S We report a simple approach to fabricate custom-shape microcapsules using hydrogel templates synthesized by stop flow lithography. Cargo-containing microcapsules were made by coating hydrogel particles with a single layer of poly-l-lysine followed by a one-step core degradation and capsule cross-linking procedure. We determined appropriate coating conditions by investigating the effect of pH, ionic strength, and prepolymer composition on the diffusion of polyelectrolytes into the oppositely charged hydrogel template. We also characterized the degradation of the templating core by tracking the diffusivity of nanoparticles embedded within the hydrogel. Unlike any other technique, this approach allows for easy fabrication of microcapsules with internal features (e.g., toroids) and selective surface modification of Janus particles using any polyelectrolyte. These soft, flexible capsules may be useful for therapeutic applications as well as fundamental studies of membrane mechanics. United States. Army Research Office (Institute for Collaborative Biotechnologies. Grant W911NF-09-0001) National Science Foundation (U.S.) (Grants CMMI-1120724 and DMR-1006147) 2017-03-16T14:40:30Z 2017-03-16T14:40:30Z 2015-08 2015-06 Article http://purl.org/eprint/type/JournalArticle 0743-7463 1520-5827 http://hdl.handle.net/1721.1/107434 Chen, Lynna, Harry Z. An, and Patrick S. Doyle. “Synthesis of Nonspherical Microcapsules through Controlled Polyelectrolyte Coating of Hydrogel Templates.” Langmuir 31, no. 33 (August 25, 2015): 9228–9235. https://orcid.org/0000-0002-2505-3657 en_US http://dx.doi.org/10.1021/acs.langmuir.5b02200 Langmuir Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) MIT Web Domain |
| spellingShingle | Chen, Lynna An, Harry Doyle, Patrick S Synthesis of Nonspherical Microcapsules through Controlled Polyelectrolyte Coating of Hydrogel Templates |
| title | Synthesis of Nonspherical Microcapsules through Controlled Polyelectrolyte Coating of Hydrogel Templates |
| title_full | Synthesis of Nonspherical Microcapsules through Controlled Polyelectrolyte Coating of Hydrogel Templates |
| title_fullStr | Synthesis of Nonspherical Microcapsules through Controlled Polyelectrolyte Coating of Hydrogel Templates |
| title_full_unstemmed | Synthesis of Nonspherical Microcapsules through Controlled Polyelectrolyte Coating of Hydrogel Templates |
| title_short | Synthesis of Nonspherical Microcapsules through Controlled Polyelectrolyte Coating of Hydrogel Templates |
| title_sort | synthesis of nonspherical microcapsules through controlled polyelectrolyte coating of hydrogel templates |
| url | http://hdl.handle.net/1721.1/107434 https://orcid.org/0000-0002-2505-3657 |
| work_keys_str_mv | AT chenlynna synthesisofnonsphericalmicrocapsulesthroughcontrolledpolyelectrolytecoatingofhydrogeltemplates AT anharry synthesisofnonsphericalmicrocapsulesthroughcontrolledpolyelectrolytecoatingofhydrogeltemplates AT doylepatricks synthesisofnonsphericalmicrocapsulesthroughcontrolledpolyelectrolytecoatingofhydrogeltemplates |