Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes
Background Clinical activity and quality of life (QOL) indices assess disease activity in Crohn’s disease (CD) and ulcerative colitis (UC). However, a paucity of data exists on the validity of these indices according to disease characteristics. Aims To examine the correlation between QOL an...
| Main Authors: | , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer US
2017
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| Online Access: | http://hdl.handle.net/1721.1/107455 |
| _version_ | 1810983238770884608 |
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| author | Taleban, Sasha Singh, Prashant Yajnik, Vijay Khalili, Hamed Stewart, Kathleen O. Li, Darrick K. Pardi, Darrell S. Sturgeon, Holly C. Ananthakrishnan, Ashwin N. Xavier, Ramnik Joseph |
| author2 | Institute for Medical Engineering and Science |
| author_facet | Institute for Medical Engineering and Science Taleban, Sasha Singh, Prashant Yajnik, Vijay Khalili, Hamed Stewart, Kathleen O. Li, Darrick K. Pardi, Darrell S. Sturgeon, Holly C. Ananthakrishnan, Ashwin N. Xavier, Ramnik Joseph |
| author_sort | Taleban, Sasha |
| collection | MIT |
| description | Background
Clinical activity and quality of life (QOL) indices assess disease activity in Crohn’s disease (CD) and ulcerative colitis (UC). However, a paucity of data exists on the validity of these indices according to disease characteristics.
Aims
To examine the correlation between QOL and clinical activity indices and endoscopic disease activity according to disease characteristics.
Methods
We used a prospective registry to identify CD and UC patients ≥18 years old with available information on Short Inflammatory Bowel Disease Questionnaire scores (SIBDQ), Harvey–Bradshaw Index (HBI) and simple endoscopic scores for CD (SES-CD), and Simple Clinical Colitis Activity Index (SCCAI) and Mayo endoscopic score for UC. We used Spearman rank correlations to calculate correlations between indices and Fisher transformation to compare correlations across disease characteristics.
Results
Among 282 CD patients, we observed poor correlation between clinical activity and QOL indices to SES-CD with no differences in correlation according to disease characteristics. Conversely, among 226 UC patients, clinical activity and QOL had good correlation to Mayo endoscopic score (r = 0.55 and −0.56, respectively) with better correlations observed with left-sided versus extensive colitis (r = 0.73 vs. 0.45, p = 0.005) and shorter duration of disease (r = 0.61 vs. 0.37, p = 0.04).
Conclusions
Our data suggest good correlation between SCCAI and endoscopic disease activity in UC, particularly in left-sided disease. Poor correlations between HBI or SIBDQ and SES-CD appear to be consistent across different disease phenotypes. |
| first_indexed | 2024-09-23T10:43:22Z |
| format | Article |
| id | mit-1721.1/107455 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:43:22Z |
| publishDate | 2017 |
| publisher | Springer US |
| record_format | dspace |
| spelling | mit-1721.1/1074552022-09-30T22:32:56Z Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes Taleban, Sasha Singh, Prashant Yajnik, Vijay Khalili, Hamed Stewart, Kathleen O. Li, Darrick K. Pardi, Darrell S. Sturgeon, Holly C. Ananthakrishnan, Ashwin N. Xavier, Ramnik Joseph Institute for Medical Engineering and Science Xavier, Ramnik Joseph Background Clinical activity and quality of life (QOL) indices assess disease activity in Crohn’s disease (CD) and ulcerative colitis (UC). However, a paucity of data exists on the validity of these indices according to disease characteristics. Aims To examine the correlation between QOL and clinical activity indices and endoscopic disease activity according to disease characteristics. Methods We used a prospective registry to identify CD and UC patients ≥18 years old with available information on Short Inflammatory Bowel Disease Questionnaire scores (SIBDQ), Harvey–Bradshaw Index (HBI) and simple endoscopic scores for CD (SES-CD), and Simple Clinical Colitis Activity Index (SCCAI) and Mayo endoscopic score for UC. We used Spearman rank correlations to calculate correlations between indices and Fisher transformation to compare correlations across disease characteristics. Results Among 282 CD patients, we observed poor correlation between clinical activity and QOL indices to SES-CD with no differences in correlation according to disease characteristics. Conversely, among 226 UC patients, clinical activity and QOL had good correlation to Mayo endoscopic score (r = 0.55 and −0.56, respectively) with better correlations observed with left-sided versus extensive colitis (r = 0.73 vs. 0.45, p = 0.005) and shorter duration of disease (r = 0.61 vs. 0.37, p = 0.04). Conclusions Our data suggest good correlation between SCCAI and endoscopic disease activity in UC, particularly in left-sided disease. Poor correlations between HBI or SIBDQ and SES-CD appear to be consistent across different disease phenotypes. American Gastroenterological Association 2017-03-16T23:01:47Z 2017-03-16T23:01:47Z 2016-05 2016-02 2017-02-02T15:21:16Z Article http://purl.org/eprint/type/JournalArticle 0163-2116 1573-2568 http://hdl.handle.net/1721.1/107455 Taleban, Sasha, Kathleen O. Stewart, Darrick K. Li, Prashant Singh, Darrell S. Pardi, Holly C. Sturgeon, Vijay Yajnik, Ramnik J. Xavier, Ashwin N. Ananthakrishnan, and Hamed Khalili. “Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes.” Digestive Diseases and Sciences 61, no. 9 (May 3, 2016): 2627–2635. en http://dx.doi.org/10.1007/s10620-016-4180-8 Digestive Diseases and Sciences Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. Springer Science+Business Media New York application/pdf Springer US Springer US |
| spellingShingle | Taleban, Sasha Singh, Prashant Yajnik, Vijay Khalili, Hamed Stewart, Kathleen O. Li, Darrick K. Pardi, Darrell S. Sturgeon, Holly C. Ananthakrishnan, Ashwin N. Xavier, Ramnik Joseph Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes |
| title | Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes |
| title_full | Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes |
| title_fullStr | Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes |
| title_full_unstemmed | Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes |
| title_short | Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes |
| title_sort | clinical activity and quality of life indices are valid across ulcerative colitis but not crohn s disease phenotypes |
| url | http://hdl.handle.net/1721.1/107455 |
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