Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

Cellular proliferation depends on refilling the tricarboxylic acid (TCA) cycle to support biomass production (anaplerosis). The two major anaplerotic pathways in cells are pyruvate conversion to oxaloacetate via pyruvate carboxylase (PC) and glutamine conversion to α-ketoglutarate. Cancers often sho...

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Bibliographic Details
Main Authors:	Christen, Stefan, Lorendeau, Doriane, Schmieder, Roberta, Broekaert, Dorien, Metzger, Kristine, Veys, Koen, Elia, Ilaria, Buescher, Joerg Martin, Orth, Martin Franz, Grünewald, Thomas Georg Philipp, De Bock, Katrien, Fendt, Sarah-Maria, Davidson, Shawn Michael
Other Authors:	Koch Institute for Integrative Cancer Research at MIT
Format:	Article
Language:	en_US
Published:	Elsevier 2017
Online Access:	http://hdl.handle.net/1721.1/107487 https://orcid.org/0000-0003-0701-5275

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